ID   NTPC_ENTHA              Reviewed;         328 AA.
AC   P43456; I6SYM8;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=V-type sodium ATPase subunit C;
DE   AltName: Full=Na(+)-translocating ATPase subunit C;
DE   AltName: Full=V-type sodium pump subunit C;
GN   Name=ntpC; Synonyms=ntpP; OrderedLocusNames=EHR_08250;
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-16.
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8157629; DOI=10.1016/s0021-9258(19)78088-0;
RA   Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.;
RT   "Sequencing and characterization of the ntp gene cluster for vacuolar-type
RT   Na(+)-translocating ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:11037-11044(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8144530; DOI=10.1016/s0021-9258(17)36902-8;
RA   Solioz M., Davies K.;
RT   "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:9453-9459(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=22933757; DOI=10.1128/jb.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- FUNCTION: Involved in ATP-driven sodium extrusion.
CC   -!- SIMILARITY: Belongs to the V-ATPase V0D/AC39 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; D17462; BAA04273.1; -; Genomic_DNA.
DR   EMBL; X76913; CAA54239.1; -; Genomic_DNA.
DR   EMBL; CP003504; AFM70577.1; -; Genomic_DNA.
DR   PIR; E54392; E54392.
DR   RefSeq; WP_010738013.1; NZ_KB946231.1.
DR   AlphaFoldDB; P43456; -.
DR   SMR; P43456; -.
DR   STRING; 768486.EHR_08250; -.
DR   TCDB; 3.A.2.2.2; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR   EnsemblBacteria; AFM70577; AFM70577; EHR_08250.
DR   KEGG; ehr:EHR_08250; -.
DR   eggNOG; COG1527; Bacteria.
DR   HOGENOM; CLU_059311_1_0_9; -.
DR   OrthoDB; 1532119at2; -.
DR   BioCyc; MetaCyc:MON-14148; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.50; -; 1.
DR   Gene3D; 1.20.1690.10; -; 2.
DR   InterPro; IPR036079; ATPase_su_c/d_sf.
DR   InterPro; IPR002843; ATPase_V0-cplx_csu/dsu.
DR   InterPro; IPR044911; V-type_ATPase_su_c/d_dom_3.
DR   InterPro; IPR035067; V-type_ATPase_suC/d.
DR   Pfam; PF01992; vATP-synt_AC39; 1.
DR   SUPFAM; SSF103486; SSF103486; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion transport; Sodium; Sodium transport;
KW   Transport.
FT   CHAIN           1..328
FT                   /note="V-type sodium ATPase subunit C"
FT                   /id="PRO_0000119377"
SQ   SEQUENCE   328 AA;  38163 MW;  44B2D7908CD835E7 CRC64;
     MEYHELNPLI RGRELELISK DTFEQMIQTD SIDSLGEILQ STIYQPYIYD GFDKDFEANL
     SQERSKLFQW LKESAPEPEI VWIYTMRYTF HNLKVLTKAE ITGQNLDHLY IHDGFYSLEV
     LKDAIHTQVS VELPDSLMDY IREVHEYCEE STILQGIDVI YDRCFLTEQR RLGEQLGYPE
     LLEEIIAFID LTNITTTARG ILQHRSAGFM TTVISSSGSI PKDTLLSFVR GEMASFTQFL
     LTTDYSELLK QVIHEEQIDL VSLEQLKDDY LSSFYQVAQT QAFGPLPLLA FLNAKEVESK
     NLRLLIIGKR NHFSLEQLKE RMRQVYDL