ID   NTPD_ENTHA              Reviewed;         210 AA.
AC   P43435; I6T729;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=V-type sodium ATPase subunit D;
DE   AltName: Full=Na(+)-translocating ATPase subunit D;
DE   AltName: Full=V-type sodium pump subunit D;
GN   Name=ntpD; OrderedLocusNames=EHR_08270;
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-14, AND FUNCTION.
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8157629; DOI=10.1016/s0021-9258(19)78088-0;
RA   Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.;
RT   "Sequencing and characterization of the ntp gene cluster for vacuolar-type
RT   Na(+)-translocating ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:11037-11044(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=22933757; DOI=10.1128/jb.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- FUNCTION: Involved in ATP-driven sodium extrusion.
CC       {ECO:0000269|PubMed:8157629}.
CC   -!- SIMILARITY: Belongs to the V-ATPase D subunit family. {ECO:0000305}.
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DR   EMBL; D17462; BAA04277.1; -; Genomic_DNA.
DR   EMBL; CP003504; AFM70581.1; -; Genomic_DNA.
DR   PIR; F53610; F53610.
DR   RefSeq; WP_010738012.1; NZ_KB946231.1.
DR   PDB; 3AON; X-ray; 2.00 A; A=1-210.
DR   PDB; 3VR4; X-ray; 2.17 A; G=1-210.
DR   PDB; 3VR5; X-ray; 3.90 A; G=1-210.
DR   PDB; 3VR6; X-ray; 2.68 A; G=1-210.
DR   PDB; 5KNB; X-ray; 3.25 A; G=1-210.
DR   PDB; 5KNC; X-ray; 3.02 A; G=1-210.
DR   PDB; 5KND; X-ray; 2.89 A; G=1-210.
DR   PDBsum; 3AON; -.
DR   PDBsum; 3VR4; -.
DR   PDBsum; 3VR5; -.
DR   PDBsum; 3VR6; -.
DR   PDBsum; 5KNB; -.
DR   PDBsum; 5KNC; -.
DR   PDBsum; 5KND; -.
DR   AlphaFoldDB; P43435; -.
DR   SMR; P43435; -.
DR   DIP; DIP-59796N; -.
DR   IntAct; P43435; 2.
DR   STRING; 768486.EHR_08270; -.
DR   TCDB; 3.A.2.2.2; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR   EnsemblBacteria; AFM70581; AFM70581; EHR_08270.
DR   KEGG; ehr:EHR_08270; -.
DR   eggNOG; COG1394; Bacteria.
DR   HOGENOM; CLU_069688_2_1_9; -.
DR   BioCyc; MetaCyc:MON-14149; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_00271; ATP_synth_D_arch; 1.
DR   InterPro; IPR002699; V_ATPase_D.
DR   PANTHER; PTHR11671; PTHR11671; 1.
DR   Pfam; PF01813; ATP-synt_D; 1.
DR   TIGRFAMs; TIGR00309; V_ATPase_subD; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Ion transport; Sodium;
KW   Sodium transport; Transport.
FT   CHAIN           1..210
FT                   /note="V-type sodium ATPase subunit D"
FT                   /id="PRO_0000144275"
FT   CONFLICT        201..210
FT                   /note="IKVKNMGTEE -> SQSEKYGNRRVRLIQFSILMAFFMIRTNRI (in
FT                   Ref. 1; BAA04277)"
FT                   /evidence="ECO:0000305"
FT   HELIX           9..69
FT                   /evidence="ECO:0007829|PDB:3AON"
FT   HELIX           74..81
FT                   /evidence="ECO:0007829|PDB:3AON"
FT   STRAND          89..97
FT                   /evidence="ECO:0007829|PDB:3AON"
FT   STRAND          100..108
FT                   /evidence="ECO:0007829|PDB:3AON"
FT   HELIX           111..113
FT                   /evidence="ECO:0007829|PDB:3AON"
FT   HELIX           127..172
FT                   /evidence="ECO:0007829|PDB:3AON"
FT   HELIX           174..193
FT                   /evidence="ECO:0007829|PDB:3AON"
SQ   SEQUENCE   210 AA;  24566 MW;  6779016F1921BC85 CRC64;
     MRLNVNPTRM ELTRLKKQLT TATRGHKLLK DKQDELMRQF ILLIRKNNEL RQAIEKETQT
     AMKDFVLAKS TVEEAFIDEL LALPAENVSI SVVEKNIMSV KVPLMNFQYD ETLNETPLEY
     GYLHSNAELD RSIDGFTQLL PKLLKLAEVE KTCQLMAEEI EKTRRRVNAL EYMTIPQLEE
     TIYYIKMKLE ENERAEVTRL IKVKNMGTEE