ID   NTPE_ENTHA              Reviewed;         193 AA.
AC   P43436; I6T726;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=V-type sodium ATPase subunit E;
DE   AltName: Full=Na(+)-translocating ATPase subunit E;
DE   AltName: Full=V-type sodium pump subunit E;
GN   Name=ntpE; Synonyms=ntpO; OrderedLocusNames=EHR_08245;
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8157629; DOI=10.1016/s0021-9258(19)78088-0;
RA   Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.;
RT   "Sequencing and characterization of the ntp gene cluster for vacuolar-type
RT   Na(+)-translocating ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:11037-11044(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8144530; DOI=10.1016/s0021-9258(17)36902-8;
RA   Solioz M., Davies K.;
RT   "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:9453-9459(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=22933757; DOI=10.1128/jb.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- FUNCTION: Involved in ATP-driven sodium extrusion.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the V-ATPase E subunit family. {ECO:0000305}.
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DR   EMBL; D17462; BAA04272.1; -; Genomic_DNA.
DR   EMBL; X76913; CAA54238.1; -; Genomic_DNA.
DR   EMBL; CP003504; AFM70576.1; -; Genomic_DNA.
DR   PIR; C53610; C53610.
DR   RefSeq; WP_014834502.1; NC_018081.1.
DR   AlphaFoldDB; P43436; -.
DR   SMR; P43436; -.
DR   STRING; 768486.EHR_08245; -.
DR   TCDB; 3.A.2.2.2; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR   EnsemblBacteria; AFM70576; AFM70576; EHR_08245.
DR   KEGG; ehr:EHR_08245; -.
DR   PATRIC; fig|768486.3.peg.1572; -.
DR   eggNOG; COG1390; Bacteria.
DR   HOGENOM; CLU_105846_2_1_9; -.
DR   OrthoDB; 1459550at2; -.
DR   BioCyc; MetaCyc:MON-14150; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0033178; C:proton-transporting two-sector ATPase complex, catalytic domain; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_00311; ATP_synth_E_arch; 1.
DR   InterPro; IPR002842; ATPase_V1_Esu.
PE   3: Inferred from homology;
KW   Ion transport; Sodium; Sodium transport; Transport.
FT   CHAIN           1..193
FT                   /note="V-type sodium ATPase subunit E"
FT                   /id="PRO_0000117336"
FT   CONFLICT        1..2
FT                   /note="MP -> MTVDA (in Ref. 1; BAA04272)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   193 AA;  22611 MW;  0657B0F53E99E110 CRC64;
     MPIDKIITQI NETAQLERAS FEEMKRKEID QKFEVKKWQI EADFQKEKAS KLEEIERSYR
     QLRNKQKMQV KQEILNAKQE VLQRLFTEAT LQLENEPKEE QLALMKQMIQ TLPINGTARL
     IPGEKSADIL TPAVIAEWNE ELPFELIRED FTEKAQAGLI IDDAGIQYNF LFSHLIKEIQ
     ETMSAEIAKE LFD