ID   NTPI_ENTHA              Reviewed;         664 AA.
AC   P43439; I6TB87;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=V-type sodium ATPase subunit I;
DE   AltName: Full=Na(+)-translocating ATPase subunit I;
DE   AltName: Full=V-type sodium pump subunit I;
GN   Name=ntpI; Synonyms=ntpM; OrderedLocusNames=EHR_08235;
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8157629; DOI=10.1016/s0021-9258(19)78088-0;
RA   Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.;
RT   "Sequencing and characterization of the ntp gene cluster for vacuolar-type
RT   Na(+)-translocating ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:11037-11044(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8144530; DOI=10.1016/s0021-9258(17)36902-8;
RA   Solioz M., Davies K.;
RT   "Operon of vacuolar-type Na(+)-ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:9453-9459(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=22933757; DOI=10.1128/jb.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- FUNCTION: Involved in ATP-driven sodium extrusion.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000305}.
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DR   EMBL; D17462; BAA04270.1; -; Genomic_DNA.
DR   EMBL; X76913; CAA54236.1; -; Genomic_DNA.
DR   EMBL; CP003504; AFM70574.1; -; Genomic_DNA.
DR   PIR; B53610; B53610.
DR   RefSeq; WP_010738016.1; NZ_KB946231.1.
DR   AlphaFoldDB; P43439; -.
DR   SMR; P43439; -.
DR   STRING; 768486.EHR_08235; -.
DR   TCDB; 3.A.2.2.2; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.
DR   EnsemblBacteria; AFM70574; AFM70574; EHR_08235.
DR   KEGG; ehr:EHR_08235; -.
DR   eggNOG; COG1269; Bacteria.
DR   HOGENOM; CLU_025558_1_0_9; -.
DR   OrthoDB; 259071at2; -.
DR   BioCyc; MetaCyc:MON-14154; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..664
FT                   /note="V-type sodium ATPase subunit I"
FT                   /id="PRO_0000119244"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        496..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        522..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        574..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        601..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        501
FT                   /note="G -> W (in Ref. 1; BAA04270)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        515
FT                   /note="I -> T (in Ref. 1; BAA04270)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   664 AA;  75504 MW;  A914002F489C70B6 CRC64;
     MAVTKMEKVT LISDKKNREI LLQAVQGLHA VEIRDLFQES ENNQWVETFF PEPEMIDKDK
     ELAKLSYKLT DIRTAIQFIE HHGEKSQKKQ HLKRRELSLD TLEKNYSEEA FSKKLEEVLL
     LKEQWEQLVD ERQQLEDQEN WLLNWQNLDL APKAFDSQMT KLVIGTVNAK NAESFKAEVA
     EINEAYLEEI NSSPTTTYFA YIVLRADESR MEEIASRYGF VKEDYLYEGT PQQQLVAAKQ
     SLQEIKDQQK KLSSAIGACS GYIKDFEWTE EIFLARSERE AIKDRIIHTP YLILIQGWVD
     HEEKQELIHM LQNILASEEV YLTFDEPTDN EIAEEVPTKL KNHPIVAPFE MLTEMYSLPK
     YEEVDPTPWM MPFYLVFFGM MVADIGYGLL MFLGAFLLQK LVVLPRGMQR FAKFFEILAI
     PSIIWGFIYS SFFGAALPKE IFGIHLPFPI LSTTDDVNTI LILSVIFGLI QILVGLFIAA
     KEHIKRKAYV DAVNDGFAWQ GILLGIILIL LGTMILKNNA FVYLGGALAV LSAVCILIIP
     VFQSSSKAKG IAKGAYNLYG LTGYIGDLVS YTRLMALGIS GGSIAAAFNM LVAFMPPAAR
     FSVGILLIIV LQALNMFLTL LSAYVHGARL QYVEFFGKFY TGGGRSFKPL KTVEKYVNIN
     HKKK