ID   NTPPB_DICDI             Reviewed;         197 AA.
AC   Q54TC5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=7-methyl-GTP pyrophosphatase {ECO:0000250|UniProtKB:P0A729};
DE            Short=m(7)GTP pyrophosphatase {ECO:0000250|UniProtKB:P0A729};
DE            EC=3.6.1.- {ECO:0000250|UniProtKB:P0A729};
DE   AltName: Full=Maf-like protein DDB_G0281937;
GN   ORFNames=DDB_G0281937;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-
CC       methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and
CC       in preventing the incorporation of modified nucleotides into cellular
CC       nucleic acids. {ECO:0000250|UniProtKB:P0A729}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(7)-methyl-GTP = diphosphate + H(+) + N(7)-methyl-GMP;
CC         Xref=Rhea:RHEA:58744, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58285, ChEBI:CHEBI:87133;
CC         Evidence={ECO:0000250|UniProtKB:P0A729};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Maf family. YceF subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000043; EAL66528.1; -; Genomic_DNA.
DR   RefSeq; XP_640464.1; XM_635372.1.
DR   AlphaFoldDB; Q54TC5; -.
DR   SMR; Q54TC5; -.
DR   STRING; 44689.DDB0267059; -.
DR   PaxDb; Q54TC5; -.
DR   EnsemblProtists; EAL66528; EAL66528; DDB_G0281937.
DR   GeneID; 8623277; -.
DR   KEGG; ddi:DDB_G0281937; -.
DR   dictyBase; DDB_G0281937; -.
DR   eggNOG; KOG1509; Eukaryota.
DR   HOGENOM; CLU_040416_4_1_1; -.
DR   InParanoid; Q54TC5; -.
DR   OMA; EEVCGFC; -.
DR   PhylomeDB; Q54TC5; -.
DR   PRO; PR:Q54TC5; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IBA:GO_Central.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.950.10; -; 1.
DR   HAMAP; MF_00528; Maf; 1.
DR   InterPro; IPR029001; ITPase-like_fam.
DR   InterPro; IPR003697; Maf-like.
DR   PANTHER; PTHR43213; PTHR43213; 1.
DR   Pfam; PF02545; Maf; 1.
DR   PIRSF; PIRSF006305; Maf; 1.
DR   SUPFAM; SSF52972; SSF52972; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Nucleotide metabolism; Reference proteome.
FT   CHAIN           1..197
FT                   /note="7-methyl-GTP pyrophosphatase"
FT                   /id="PRO_0000331374"
FT   ACT_SITE        79
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P0A729"
FT   SITE            14
FT                   /note="Important for substrate specificity"
FT                   /evidence="ECO:0000250|UniProtKB:P0A729"
FT   SITE            80
FT                   /note="Important for substrate specificity"
FT                   /evidence="ECO:0000250|UniProtKB:P0A729"
FT   SITE            164
FT                   /note="Important for substrate specificity"
FT                   /evidence="ECO:0000250|UniProtKB:P0A729"
SQ   SEQUENCE   197 AA;  22118 MW;  A4CB40699BACF32E CRC64;
     MTSRPLILGS SSIWRKQVLI DMGYIFKTMS PDIDEKAIRD SDPKTLTLLI SRAKAQALLK
     RIKESDDELD KKSIMICSDQ VIVHNGVIRE KPETEQQCRE YLQSYEFHPA VAVVSVVVVN
     IETGKIVEGT DIATQHFKKI SDEFIDKLIK QGDVMHCAGG FTVEHMADFT LQLEGEVETI
     LGLPKTLTKN LISQVSQ