NTPP_DICDI
ID NTPP_DICDI Reviewed; 216 AA.
AC Q55G28;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Nucleoside triphosphate pyrophosphatase {ECO:0000250|UniProtKB:Q99210};
DE EC=3.6.1.9 {ECO:0000250|UniProtKB:Q99210};
DE AltName: Full=Maf-like protein DDB_G0267852;
DE AltName: Full=Nucleotide pyrophosphatase {ECO:0000250|UniProtKB:Q99210};
DE Short=Nucleotide PPase {ECO:0000250|UniProtKB:Q99210};
GN ORFNames=DDB_G0267852;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Nucleoside triphosphate pyrophosphatase. May have a dual role
CC in cell division arrest and in preventing the incorporation of modified
CC nucleotides into cellular nucleic acids.
CC {ECO:0000250|UniProtKB:Q99210}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9;
CC Evidence={ECO:0000305};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside 5'-phosphate + diphosphate + H(+);
CC Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9;
CC Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250|UniProtKB:Q99210};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Maf family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73379.1; -; Genomic_DNA.
DR RefSeq; XP_647355.1; XM_642263.1.
DR AlphaFoldDB; Q55G28; -.
DR SMR; Q55G28; -.
DR STRING; 44689.DDB0305286; -.
DR PaxDb; Q55G28; -.
DR EnsemblProtists; EAL73379; EAL73379; DDB_G0267852.
DR GeneID; 8616166; -.
DR KEGG; ddi:DDB_G0267852; -.
DR dictyBase; DDB_G0267852; -.
DR eggNOG; KOG1509; Eukaryota.
DR HOGENOM; CLU_040416_0_2_1; -.
DR InParanoid; Q55G28; -.
DR OMA; RIDGDFY; -.
DR PhylomeDB; Q55G28; -.
DR PRO; PR:Q55G28; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0036218; F:dTTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0035529; F:NADH pyrophosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IBA:GO_Central.
DR CDD; cd00555; Maf; 1.
DR Gene3D; 3.90.950.10; -; 1.
DR HAMAP; MF_00528; Maf; 1.
DR InterPro; IPR029001; ITPase-like_fam.
DR InterPro; IPR003697; Maf-like.
DR PANTHER; PTHR43213; PTHR43213; 1.
DR Pfam; PF02545; Maf; 1.
DR PIRSF; PIRSF006305; Maf; 1.
DR SUPFAM; SSF52972; SSF52972; 1.
DR TIGRFAMs; TIGR00172; maf; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..216
FT /note="Nucleoside triphosphate pyrophosphatase"
FT /id="PRO_0000331373"
FT ACT_SITE 86
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q99210"
SQ SEQUENCE 216 AA; 24511 MW; 67C86B0B1BE874CB CRC64;
MILDILVKLN KLKIILASTS PRRIEYLGKL GVKFEIVESK FKEDLDKSQF QSVYDYCLEN
AKLKAIHAGI QLKEQNQQPN IIIGSDSIVV YDNKIFEKPK SLEEAKSMLT LLSGKIHTVC
TAVHIEFFNE NTNSKGSSSF YTLTNVEFDQ LSPELINYYV DNFKPLDKAG SYGIQQTPAA
SFIKSINGDF YNVTGLPIHD LSINLRKIYV DNFLEK
