ID   NTPR_ENTHA              Reviewed;         239 AA.
AC   P49865; I6SYM3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Protein NtpR;
GN   Name=ntpR; OrderedLocusNames=EHR_08225;
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=22933757; DOI=10.1128/jb.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459
RC   / NCDO 1258 / NCTC 12367 / WDCM 00089 / R;
RX   PubMed=8157629; DOI=10.1016/s0021-9258(19)78088-0;
RA   Takase K., Kakinuma S., Yamato I., Konishi K., Igarashi K., Kakinuma Y.;
RT   "Sequencing and characterization of the ntp gene cluster for vacuolar-type
RT   Na(+)-translocating ATPase of Enterococcus hirae.";
RL   J. Biol. Chem. 269:11037-11044(1994).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003504; AFM70572.1; -; Genomic_DNA.
DR   EMBL; D17462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_010738018.1; NZ_KB946231.1.
DR   AlphaFoldDB; P49865; -.
DR   SMR; P49865; -.
DR   STRING; 768486.EHR_08225; -.
DR   MEROPS; C26.965; -.
DR   EnsemblBacteria; AFM70572; AFM70572; EHR_08225.
DR   KEGG; ehr:EHR_08225; -.
DR   eggNOG; COG2071; Bacteria.
DR   HOGENOM; CLU_030756_2_1_9; -.
DR   OrthoDB; 1628378at2; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR011697; Peptidase_C26.
DR   InterPro; IPR044668; PuuD-like.
DR   PANTHER; PTHR43235; PTHR43235; 1.
DR   Pfam; PF07722; Peptidase_C26; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
PE   4: Predicted;
KW   Glutamine amidotransferase.
FT   CHAIN           1..239
FT                   /note="Protein NtpR"
FT                   /id="PRO_0000057975"
FT   DOMAIN          12..239
FT                   /note="Glutamine amidotransferase type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        113
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        219
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"
SQ   SEQUENCE   239 AA;  26541 MW;  F8100D3CF7935B6C CRC64;
     MLPIIGIAGN QLIRATDTFQ GNQVTYTPQG FVNAVQQADG LPIVLPISSP KTASAYIDQI
     DKLILAGGQD ISPQLYHEPP HPKLLETNLQ RDLFEAALIS EALKQNKPIF AVCRGMQLLN
     VVLGGSLYQD LTTYPKWSVK HEQHPTAPQF ATHEVEILPD TLLYQLLPDT YLVNSYHHQA
     LKELAPSLKA TAFSPDGLVE GIESLDKDVR LFGVQWHPEL THSSNSTDQG LFDFFVQEF