NTR2_HUMAN
ID NTR2_HUMAN Reviewed; 410 AA.
AC O95665; Q53QQ5; Q57Z87; Q8IY58; Q8TBH6;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Neurotensin receptor type 2;
DE Short=NT-R-2;
DE Short=NTR2;
DE AltName: Full=Levocabastine-sensitive neurotensin receptor;
GN Name=NTSR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-54.
RC TISSUE=Brain;
RX PubMed=9851594; DOI=10.1016/s0014-2999(98)00678-5;
RA Vita N., Oury-Donat F., Chalon P., Guillemot M., Kaghad M., Bachy A.,
RA Thurneyssen S., Garcia S., Poinot-Chazel C., Casellas P., Keane P.,
RA Le Fur G., Maffrand J.-P., Shoubrie P., Caput D., Ferrara P.;
RT "Neurotensin is an antagonist of the human neurotensin NT2 receptor
RT expressed in Chinese hamster ovary cells.";
RL Eur. J. Pharmacol. 360:265-272(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-54.
RC TISSUE=Brain;
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-54.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=20048080; DOI=10.1158/0008-5472.can-09-1252;
RA Swift S.L., Burns J.E., Maitland N.J.;
RT "Altered expression of neurotensin receptors is associated with the
RT differentiation state of prostate cancer.";
RL Cancer Res. 70:347-356(2010).
CC -!- FUNCTION: Receptor for the tridecapeptide neurotensin. It is associated
CC with G proteins that activate a phosphatidylinositol-calcium second
CC messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in prostate (at protein level).
CC {ECO:0000269|PubMed:20048080}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Neurotensin receptor subfamily. NTSR2 sub-subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAX00924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Neurotensin receptor entry;
CC URL="https://en.wikipedia.org/wiki/Neurotensin_receptor";
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DR EMBL; Y10148; CAA71233.1; -; mRNA.
DR EMBL; AY429107; AAR07902.1; -; mRNA.
DR EMBL; AC106875; AAY14691.1; -; Genomic_DNA.
DR EMBL; AC110754; AAX82018.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00924.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC022501; AAH22501.1; -; mRNA.
DR EMBL; BC037776; AAH37776.1; -; mRNA.
DR CCDS; CCDS1681.1; -.
DR RefSeq; NP_036476.1; NM_012344.3.
DR AlphaFoldDB; O95665; -.
DR SMR; O95665; -.
DR BioGRID; 117153; 1.
DR STRING; 9606.ENSP00000303686; -.
DR BindingDB; O95665; -.
DR ChEMBL; CHEMBL2514; -.
DR DrugBank; DB01106; Levocabastine.
DR DrugCentral; O95665; -.
DR GuidetoPHARMACOLOGY; 310; -.
DR iPTMnet; O95665; -.
DR PhosphoSitePlus; O95665; -.
DR BioMuta; NTSR2; -.
DR MassIVE; O95665; -.
DR PaxDb; O95665; -.
DR PeptideAtlas; O95665; -.
DR PRIDE; O95665; -.
DR ProteomicsDB; 50982; -.
DR Antibodypedia; 12728; 303 antibodies from 29 providers.
DR DNASU; 23620; -.
DR Ensembl; ENST00000306928.6; ENSP00000303686.5; ENSG00000169006.7.
DR GeneID; 23620; -.
DR KEGG; hsa:23620; -.
DR MANE-Select; ENST00000306928.6; ENSP00000303686.5; NM_012344.4; NP_036476.2.
DR UCSC; uc002rbq.5; human.
DR CTD; 23620; -.
DR DisGeNET; 23620; -.
DR GeneCards; NTSR2; -.
DR HGNC; HGNC:8040; NTSR2.
DR HPA; ENSG00000169006; Group enriched (brain, choroid plexus).
DR MIM; 605538; gene.
DR neXtProt; NX_O95665; -.
DR OpenTargets; ENSG00000169006; -.
DR PharmGKB; PA31822; -.
DR VEuPathDB; HostDB:ENSG00000169006; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244813; -.
DR HOGENOM; CLU_009579_6_5_1; -.
DR InParanoid; O95665; -.
DR OMA; YSFRLWG; -.
DR OrthoDB; 890529at2759; -.
DR PhylomeDB; O95665; -.
DR TreeFam; TF337167; -.
DR PathwayCommons; O95665; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; O95665; -.
DR SIGNOR; O95665; -.
DR BioGRID-ORCS; 23620; 14 hits in 1066 CRISPR screens.
DR GeneWiki; Neurotensin_receptor_2; -.
DR GenomeRNAi; 23620; -.
DR Pharos; O95665; Tchem.
DR PRO; PR:O95665; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; O95665; protein.
DR Bgee; ENSG00000169006; Expressed in nucleus accumbens and 84 other tissues.
DR Genevisible; O95665; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016492; F:G protein-coupled neurotensin receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0007600; P:sensory perception; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003986; NT2_rcpt.
DR InterPro; IPR003984; NT_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01479; NEUROTENSINR.
DR PRINTS; PR01481; NEUROTENSN2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..410
FT /note="Neurotensin receptor type 2"
FT /id="PRO_0000069949"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..337
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 381..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 377
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT DISULFID 108..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 54
FT /note="A -> V (in dbSNP:rs6432225)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9851594, ECO:0000269|Ref.2"
FT /id="VAR_049425"
FT VARIANT 282
FT /note="R -> K (in dbSNP:rs34764121)"
FT /id="VAR_061225"
FT CONFLICT 109..134
FT /note="Missing (in Ref. 5; AAH37776)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="R -> C (in Ref. 5; AAH37776)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="L -> M (in Ref. 5; AAH22501)"
FT /evidence="ECO:0000305"
FT CONFLICT 367
FT /note="K -> R (in Ref. 5; AAH22501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 410 AA; 45385 MW; 8B87DFD6923CBD42 CRC64;
METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN ALSAHVVLKA
RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP WVFGDLGCRG YYFVHELCAY
ATVLSVAGLS AERCLAVCQP LRARSLLTPR RTRWLVALSW AASLGLALPM AVIMGQKHEL
ETADGEPEPA SRVCTVLVSR TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV
PSTSTPGSST PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR
AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS SAVTPLLYNA
VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS GFGDPPETRT
