ID   NTRXL_RICCN             Reviewed;         474 AA.
AC   Q92HC2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Putative response regulator NtrX-like;
GN   OrderedLocusNames=RC0849;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system RC0849/RC0948.
CC       {ECO:0000250}.
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DR   EMBL; AE006914; AAL03387.1; -; Genomic_DNA.
DR   PIR; A97806; A97806.
DR   RefSeq; WP_010977456.1; NC_003103.1.
DR   AlphaFoldDB; Q92HC2; -.
DR   SMR; Q92HC2; -.
DR   EnsemblBacteria; AAL03387; AAL03387; RC0849.
DR   KEGG; rco:RC0849; -.
DR   PATRIC; fig|272944.4.peg.967; -.
DR   HOGENOM; CLU_000445_0_6_5; -.
DR   OMA; PTNSRVM; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..474
FT                   /note="Putative response regulator NtrX-like"
FT                   /id="PRO_0000282382"
FT   DOMAIN          5..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          143..368
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         171..178
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         231..240
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   474 AA;  53567 MW;  3D711F3D1ACAF206 CRC64;
     MSQLDVLIVD DEESIRNLIA ANLKDEGFNP KVAANSTQAL KILSEKPVSA VVLDIWLQGS
     EIDGLGILEI IKKRYPLMPV IIISGHGTIE TAVNAIKMGA YDYIEKPFNN DKLVILLTRA
     CEVTKLKREN IDLKSKVIDK TELVGECSVT LKYKMAIAKA ATSSCRIMIH GKVGSGKELA
     ARLIHKQSKR VNNPFIIFSP TCMTTEKINQ ELFGELEKQA NNKRPTILEF ANNGTLYIDE
     VSNIPIPIQV KLLKFLKDQT ITKPCGKNIK IDIKIITGTS KNIQDEVNNG KFLEDLYYRL
     NVSSLKVPSL YERKEDIPLL VKYFVKQLSK FSGLKERSFA DETIAALQSY EWPGNIRQLR
     NVVEWTLIMN PLTTGNNEII KPYMIPSEIL ANSANLTKLE DSFDMLSMPL REAREVFERQ
     YLSAQMSRFN NNISKTSSFV GMERSALHRK LKLLSLHIPP TNRINDEEYE EANA