ID   NTRXL_RICFE             Reviewed;         475 AA.
AC   Q4UL27;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative response regulator NtrX-like;
GN   OrderedLocusNames=RF_0895;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system
CC       RF_0895/RF_0427. {ECO:0000250}.
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DR   EMBL; CP000053; AAY61746.1; -; Genomic_DNA.
DR   RefSeq; WP_011271221.1; NC_007109.1.
DR   AlphaFoldDB; Q4UL27; -.
DR   SMR; Q4UL27; -.
DR   STRING; 315456.RF_0895; -.
DR   EnsemblBacteria; AAY61746; AAY61746; RF_0895.
DR   KEGG; rfe:RF_0895; -.
DR   eggNOG; COG2204; Bacteria.
DR   HOGENOM; CLU_000445_0_6_5; -.
DR   OMA; PTNSRVM; -.
DR   OrthoDB; 123059at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..475
FT                   /note="Putative response regulator NtrX-like"
FT                   /id="PRO_0000282383"
FT   DOMAIN          5..121
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          143..369
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         171..178
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         232..241
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   475 AA;  53782 MW;  3A43711C016F6EA4 CRC64;
     MSQLDVLIVD DEESIRNLIA ANLKDEGFNP KVAANSTQAL KILSEKPVSA VILDIWLQGS
     EIDGLGILEI IKKRYPLMPV IIISGHGTIE TAVNAIKMGA YDYIEKPFNN DKLVILLKRA
     CEVTKLKREN IDLKSKVIDK TELVGGCSVT LKYKMEIEKA ASSSSRIMIH GKVGSGKELA
     ARLIHKQSKR VNNPFIIFSP TCMTTEKINQ ELFGESEKQE NNTKRPTILE FANNGTLYID
     EVSNIPIPIQ VKLLKFLKDQ TITKPCGKNI KVDIKIITGT SKNIQDEVNN GKFLEDLYYR
     LNVSSLKVPS LYERKEDIPL LVKYFVKQLS KFSGLKERNF ADETIAALQS YEWPGNIRQL
     RNVVEWTLIM NPLTTGNNEI IKPYMIPSEI LANSANLTKL EDSFDMLSMP LREAREVFER
     QYLSAQMSRF NNNISKTSSF VGMERSALHR KLKLLSLHIP PTNRINEEEY EEANA