ID   NTRYL_RICFE             Reviewed;         599 AA.
AC   Q4UMD4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Putative sensor histidine kinase NtrY-like;
DE            EC=2.7.13.3;
GN   OrderedLocusNames=RF_0427;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system
CC       RF_0427/RF_0895. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CP000053; AAY61278.1; -; Genomic_DNA.
DR   RefSeq; WP_011270762.1; NC_007109.1.
DR   AlphaFoldDB; Q4UMD4; -.
DR   SMR; Q4UMD4; -.
DR   STRING; 315456.RF_0427; -.
DR   EnsemblBacteria; AAY61278; AAY61278; RF_0427.
DR   KEGG; rfe:RF_0427; -.
DR   eggNOG; COG5000; Bacteria.
DR   HOGENOM; CLU_019564_1_0_5; -.
DR   OMA; SKFARMP; -.
DR   OrthoDB; 692375at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR045671; NtrY-like_N.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF19312; NtrY_N; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Transferase; Transmembrane; Transmembrane helix;
KW   Two-component regulatory system.
FT   CHAIN           1..599
FT                   /note="Putative sensor histidine kinase NtrY-like"
FT                   /id="PRO_0000282374"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          307..361
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          378..589
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         381
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   599 AA;  67259 MW;  BC82018C098228E9 CRC64;
     MLSYLKKNLR SYFSSRVLIF TLAIAAIIFA CATFYVISLE SKNFSTIIGF LLVDLAIFLI
     LGVLLTQKFF TQNSNNDSSK LQNRIVIAFS LVAAIPTIIV SVFSVYFFNL SVQAWFDKKI
     STVLDQSVIV AESYIAEHKL QLKETALAVA EDLSDMYYDL IHNPALFTKT LNTEAEMRSL
     DEAIVLNKST NTIVANSYLS FSLSFATIPA HLIKKADLGE PVEVKSDPTK IRMLIKLKEY
     NDVYLLVGRL VDNKIIDHID ATNGAAAEYN SLKNEIDNIQ IKFSIMFIFI ALLLLFVAIS
     FGVIFTAKIV KPIKKLVTAT DKVKDGDLTV QVPENEVDKD EIGTLYAAFN RMIKQLSRQQ
     RDLVIAQRAM AWSDVAKKVA HEIKNPLTPI LLASERLLKK FSPEIKEKEE FENYLKMIIR
     HTNDIKNIVS EFVLFARLPA PKFTKSELVY LVKHIVEARK LLNDNILYKF ESNVDQFDFM
     CDATQINQVM INLLKNAEES IEGRESGKIE VTIDAKDDFI SVIVIDSGKG FPPELIGKAT
     ESYVTTSSKG MGVGLAIVKR IVEEHCGILD IANREEEGAI IDIKFDLKKL DLKVGRSGG