NU107_SCHPO
ID NU107_SCHPO Reviewed; 813 AA.
AC Q10331; O94351;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 4.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Nucleoporin nup107;
DE AltName: Full=Nuclear pore protein nup107;
GN Name=nup107; ORFNames=SPBC428.01c, SPBC582.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP IDENTIFICATION, AND SUBCELLULAR LOCATION.
RX PubMed=11309419; DOI=10.1083/jcb.153.2.397;
RA Tran P.T., Marsh L., Doye V., Inoue S., Chang F.;
RT "A mechanism for nuclear positioning in fission yeast based on microtubule
RT pushing.";
RL J. Cell Biol. 153:397-411(2001).
RN [4]
RP FUNCTION.
RX PubMed=12618370; DOI=10.1101/gr.636103;
RA Decottignies A., Sanchez-Perez I., Nurse P.;
RT "Schizosaccharomyces pombe essential genes: a pilot study.";
RL Genome Res. 13:399-406(2003).
RN [5]
RP IDENTIFICATION IN NUP107-120 COMPLEX, INTERACTION WITH NUP120; NUP131 AND
RP NUP132, AND SUBCELLULAR LOCATION.
RX PubMed=15226438; DOI=10.1128/mcb.24.14.6379-6392.2004;
RA Bai S.W., Rouquette J., Umeda M., Faigle W., Loew D., Sazer S., Doye V.;
RT "The fission yeast Nup107-120 complex functionally interacts with the small
RT GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution,
RT and proper cell division.";
RL Mol. Cell. Biol. 24:6379-6392(2004).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors. Active directional transport is assured by both, a Phe-Gly
CC (FG) repeat affinity gradient for these transport factors across the
CC NPC and a transport cofactor concentration gradient across the nuclear
CC envelope. {ECO:0000269|PubMed:12618370}.
CC -!- SUBUNIT: Component of the npc107-120 complex which consists of nup85,
CC nup107, nup120, nup131, nup132 and seh1. Interacts with nup120, nup131
CC and nup132. {ECO:0000269|PubMed:15226438}.
CC -!- INTERACTION:
CC Q10331; Q9P797: nup131; NbExp=2; IntAct=EBI-295788, EBI-295769;
CC Q10331; Q9UTH0: nup132; NbExp=2; IntAct=EBI-295788, EBI-295780;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC membrane {ECO:0000269|PubMed:15226438}. Nucleus, nuclear pore complex
CC {ECO:0000269|PubMed:11309419, ECO:0000269|PubMed:15226438}.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup84/Nup107 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAE54931.2; -; Genomic_DNA.
DR RefSeq; NP_001018780.2; NM_001021087.2.
DR AlphaFoldDB; Q10331; -.
DR SMR; Q10331; -.
DR BioGRID; 280331; 3.
DR IntAct; Q10331; 2.
DR STRING; 4896.SPBC428.01c.1; -.
DR iPTMnet; Q10331; -.
DR MaxQB; Q10331; -.
DR PaxDb; Q10331; -.
DR PRIDE; Q10331; -.
DR EnsemblFungi; SPBC428.01c.1; SPBC428.01c.1:pep; SPBC428.01c.
DR GeneID; 3361255; -.
DR KEGG; spo:SPBC428.01c; -.
DR PomBase; SPBC428.01c; nup107.
DR VEuPathDB; FungiDB:SPBC428.01c; -.
DR eggNOG; KOG1964; Eukaryota.
DR HOGENOM; CLU_012944_0_0_1; -.
DR InParanoid; Q10331; -.
DR OMA; MAHIVLF; -.
DR Reactome; R-SPO-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-SPO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-SPO-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-SPO-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-SPO-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-SPO-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-SPO-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-SPO-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:Q10331; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0140599; C:mitotic nuclear bridge midzone membrane domain; IDA:PomBase.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR GO; GO:0031080; C:nuclear pore outer ring; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:PomBase.
DR GO; GO:0000973; P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006407; P:rRNA export from nucleus; ISO:PomBase.
DR InterPro; IPR007252; Nup84/Nup107.
DR PANTHER; PTHR13003; PTHR13003; 1.
DR Pfam; PF04121; Nup84_Nup100; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..813
FT /note="Nucleoporin nup107"
FT /id="PRO_0000204834"
SQ SEQUENCE 813 AA; 93263 MW; 8D693CA77D5CDC40 CRC64;
MACCCYSTIL THTRLDFKTM HQNALNNATL NVLGHKKNGS SSIQELIEMD EEEAEMNQNV
VCIGPNETAV SVELGDEYEK FNIITSLKKD NLFSKDGLLY AYYELCQEKF EKCLKEDDEE
WIELWDLESR TWDLIQRLYS FRLSEQQGHI QSHAFSSRAV LEEEYYSQNP EAFENNIVFN
WARDNSSDPP SIEIRGNRWF YTREDIKMKN RGGSRFSSNI SGTIVSNLDP DADIRDDKRL
DERDDNFERQ FFHTAFCLFR SGSFEELLEL CRRTGNHWRS ASLQGILEYR DNLIDDVLQS
ETSGNKRKEL LRRSCLALTK NKRIDSYERA LYGALCGDLN SVLDVCTTWE DAMWAYYNSM
TQYNLDVYLS SKAPQTETQL PPVDSGLGLT PELIFNSLSN SSIASIQEEA SHPLIKLQTH
IICNKISEIL SSAHIQLEAI RTGNAPESGD LVTPPLLRIL THIILFLKIS GLAVDEYTSD
SIIQAYIELL ASAKKVNLVP LYIQYLSNQV QYEAYSRFLI LVDEESARSE QLQLAKKYSL
DINHAALLAV EYVYDEVVSV SPEEVHTVYL KSIEEPVEPS YKKLICTLEW LLITSQTDEL
LRFANLVYRF FLSIGELNSA YDLYTHIPSD ALNTLSSSDG EPENDSKFRD AYELMNYRAL
CRALKFYQEW EELSKQEVFE DSAVTKASTS YKVWKKKLNF ASRKCVKSFT DLLQANWLHP
STLELKPDDD PLLYKTLMTI RNLYVPELIL GLHNVYFSLE DYDSCFALAN EVASEDLKLY
HCLIKSGRLV EYVSYLGKAG ECSLSTPNGL FSL
