NU124_SCHPO
ID NU124_SCHPO Reviewed; 1159 AA.
AC Q09904;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Nucleoporin nup124;
DE AltName: Full=Nuclear pore protein nup124;
GN Name=nup124; ORFNames=SPAC30D11.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=10409764; DOI=10.1128/mcb.19.8.5768;
RA Balasundaram D., Benedik M.J., Morphew M., Dang V.-D., Levin H.L.;
RT "Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is
RT important for nuclear import and activity of retrotransposon Tf1.";
RL Mol. Cell. Biol. 19:5768-5784(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-380; SER-465 AND
RP SER-546, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Nucleoporins may be involved in both binding and
CC translocation of the proteins during nucleocytoplasmic transport. In
CC S.pombe it is required for the nuclear localization of retrotransposon
CC tf1. {ECO:0000269|PubMed:10409764}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000269|PubMed:10409764}.
CC -!- DOMAIN: Contains F-X-F-G repeats.
CC -!- SIMILARITY: To yeast nucleoporins NUP1 and NUP2. {ECO:0000305}.
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DR EMBL; AF280406; AAF90179.1; -; Genomic_DNA.
DR EMBL; CU329670; CAA91890.1; -; Genomic_DNA.
DR PIR; T38595; S62562.
DR RefSeq; NP_593213.1; NM_001018609.2.
DR AlphaFoldDB; Q09904; -.
DR BioGRID; 278724; 70.
DR STRING; 4896.SPAC30D11.04c.1; -.
DR iPTMnet; Q09904; -.
DR MaxQB; Q09904; -.
DR PaxDb; Q09904; -.
DR PRIDE; Q09904; -.
DR EnsemblFungi; SPAC30D11.04c.1; SPAC30D11.04c.1:pep; SPAC30D11.04c.
DR GeneID; 2542254; -.
DR KEGG; spo:SPAC30D11.04c; -.
DR PomBase; SPAC30D11.04c; nup124.
DR VEuPathDB; FungiDB:SPAC30D11.04c; -.
DR eggNOG; KOG4719; Eukaryota.
DR HOGENOM; CLU_275466_0_0_1; -.
DR InParanoid; Q09904; -.
DR OMA; MPMGGSK; -.
DR PhylomeDB; Q09904; -.
DR Reactome; R-SPO-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-SPO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-SPO-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-SPO-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-SPO-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-SPO-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-SPO-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-SPO-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:Q09904; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0140599; C:mitotic nuclear bridge midzone membrane domain; IDA:PomBase.
DR GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IMP:PomBase.
DR GO; GO:0000054; P:ribosomal subunit export from nucleus; ISO:PomBase.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR026054; Nucleoporin.
DR InterPro; IPR013913; Nup153_N.
DR InterPro; IPR018892; Retro-transposon_transp_CS.
DR PANTHER; PTHR23193; PTHR23193; 1.
DR Pfam; PF08604; Nup153; 2.
DR Pfam; PF10599; Nup_retrotrp_bd; 1.
PE 1: Evidence at protein level;
KW mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW Protein transport; Reference proteome; Repeat; Translocation; Transport.
FT CHAIN 1..1159
FT /note="Nucleoporin nup124"
FT /id="PRO_0000204837"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 380
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 465
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 546
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 1159 AA; 123974 MW; 852F84BA2E0619A3 CRC64;
MPPVSKNTRT SSKTVKKPYD PPQGSSRPFF TVLKRAFSSV LHPFTSGLDE KASGTASKDR
KSGRAGTKSL LTPELTPHYL GKSPRIIRVS NRSHVRTIDG IEEKVHTNTF EPRKPKQKQD
YTNSPTLFKR HDELSLKSLN SLHPSSALSK KLGSTSQHQI ATPKSSASLL NILRSLHDEQ
KNTLNISSVK QDRITEANPT CEKRKPSRSP SPMLSKKKSV ARASENEPSA KQNKSFSGND
SHKSLTDIRD KENGETEVSA KNHVPHRSSR RRRRHQRLIP IIYETLEQMD LRKPVLVNAE
VQTDSNPGNT MFIDKQDIYH RLSTPTSRKR QTLEKGHIKA FSAVDEDLDE IFACEDDVHY
TALPKQNPKS ERILEPIIAS PKDNTSDKGL LTKSAPTFEE LQASITPKPV KTSPNDTALT
LANAEDNKTF EHQPLSKDTE APKSQFSSSP TKESTTRKSE VEPPSPSKEI KSSHFSVPEF
KFEPKTEATT DKKLNVPKFE FKPTATADVQ TNRLKENEPK PTFFAQLPSK TQETPSITEN
KPSFFSQLSP KREETEKKDN APSAPASTSG FSFGGFAPKT LEEKEETKAP TFNFSLNNAS
STQDTTKPTL QFNFGSSFGK PTSNIFNDKK TSENGLASST VASESKPSAP ESKPSSGFGN
TAGSSPFSFN LTKESKEVPP TNSFSFAKKG KDEANDSLSA KASTPFSFAK PNTENVTTTA
PQFSFNFTKP NTDAKTNLLP EKTFNEEAVK QKETEKEVPP TGPKASEIKD SVSSNNAVPS
STFNFVSPFA AVSEKTNENN IPNDTTKTNG NATKRTLEQT EDAKPFAFSF GSTTEQANKK
ASTSNETTKP QLDTSSKTDG VTANAPFSFA SAFNAPKPST NTADGKDSAS NLTTPSPAFS
FGNNSGVKAS SNNNPSTNSS TAPFSFGTSN KPAFSFGSAT SKTTSEGTAP AASASAPAPT
TSAFSFGASN SSMNKEENTP MAKDAGDTAP ASGFKSGFSF GANNSPQPAS MFGTSTPAPS
SAFAFGNQSG TNPAAPAGFG GITNTATNNP PSTGFTFTPS NAGSTAAPMF GAGNTPNPSG
SINNASQAFA FGSGEPSNPA SNPPSTGFSF GAATPSAFNA SASQSPAPNG IQFNLGSSNS
QTNAPPGRKI AVPRSRRKR
