NU133_ARATH
ID NU133_ARATH Reviewed; 1285 AA.
AC F4IGA5; F4IGA4; Q9SJ43;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Nuclear pore complex protein NUP133 {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin 133 {ECO:0000303|PubMed:21189294};
DE AltName: Full=Nucleoporin Nup155-like;
GN Name=NUP133 {ECO:0000303|PubMed:21189294};
GN OrderedLocusNames=At2g05120 {ECO:0000312|Araport:AT2G05120};
GN ORFNames=F5G3.2 {ECO:0000312|EMBL:AAD29053.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION IN THE NUCLEAR PORE COMPLEX BY MASS SPECTROMETRY,
RP SUBCELLULAR LOCATION, AND NOMENCLATURE.
RX PubMed=21189294; DOI=10.1105/tpc.110.079947;
RA Tamura K., Fukao Y., Iwamoto M., Haraguchi T., Hara-Nishimura I.;
RT "Identification and characterization of nuclear pore complex components in
RT Arabidopsis thaliana.";
RL Plant Cell 22:4084-4097(2010).
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC). The NPC has an eight-
CC fold symmetrical structure comprising a central transport channel and
CC two rings, the cytoplasmic and nuclear rings, to which eight filaments
CC are attached. The cytoplasmic filaments have loose ends, while the
CC nuclear filaments are joined in a distal ring, forming a nuclear
CC basket. NPCs are highly dynamic in configuration and composition, and
CC can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160
CC subcomplex and the NUP93 subcomplex, containing approximately 30
CC different nucleoporin proteins. {ECO:0000305|PubMed:21189294}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000305|PubMed:21189294}.
CC Nucleus, nuclear pore complex {ECO:0000305|PubMed:21189294}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IGA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IGA5-2; Sequence=VSP_057124, VSP_057125;
CC -!- MISCELLANEOUS: [Isoform 2]: Derived from proteomic data. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup133 family. {ECO:0000305}.
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DR EMBL; AC007018; AAD29053.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC05897.1; -; Genomic_DNA.
DR PIR; C84465; C84465.
DR RefSeq; NP_001189511.1; NM_001202582.1. [F4IGA5-2]
DR AlphaFoldDB; F4IGA5; -.
DR BioGRID; 460; 5.
DR STRING; 3702.AT2G05120.1; -.
DR iPTMnet; F4IGA5; -.
DR PaxDb; F4IGA5; -.
DR PeptideAtlas; F4IGA5; -.
DR PRIDE; F4IGA5; -.
DR ProteomicsDB; 249209; -. [F4IGA5-1]
DR EnsemblPlants; AT2G05120.2; AT2G05120.2; AT2G05120. [F4IGA5-2]
DR GeneID; 815060; -.
DR Gramene; AT2G05120.2; AT2G05120.2; AT2G05120. [F4IGA5-2]
DR KEGG; ath:AT2G05120; -.
DR Araport; AT2G05120; -.
DR TAIR; locus:2051234; AT2G05120.
DR eggNOG; ENOG502QSRR; Eukaryota.
DR InParanoid; F4IGA5; -.
DR OrthoDB; 51227at2759; -.
DR PRO; PR:F4IGA5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IGA5; baseline and differential.
DR Genevisible; F4IGA5; AT.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR007187; Nucleoporin_Nup133/Nup155_C.
DR InterPro; IPR014908; Nucleoporin_Nup133/Nup155_N.
DR InterPro; IPR037624; Nup133-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13405; PTHR13405; 1.
DR Pfam; PF03177; Nucleoporin_C; 1.
DR Pfam; PF08801; Nucleoporin_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..1285
FT /note="Nuclear pore complex protein NUP133"
FT /id="PRO_0000431076"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 197..210
FT /note="Missing (in isoform 2)"
FT /id="VSP_057124"
FT VAR_SEQ 925..975
FT /note="Missing (in isoform 2)"
FT /id="VSP_057125"
SQ SEQUENCE 1285 AA; 144598 MW; 5E627C3B4DF14A42 CRC64;
MFSPLTKRAK QSSRNEKTPR NRVPPPDSPV TPATQNRNNF ISDRPATGTP APWAPRLSVL
ARVSPGNNGD KGVDSDQLKP VFVGEFPQLL RDEQSYPGDA CVSGGMDKET CLSWFITGSK
VFVWSHLTTL PSRKCVVLEL PVVVLVNEES GSGLQDGKSW LVNVVSWDTS AGAATRASRS
RSPVGVVMCN RKTRAVVYWS DIFSGQEAAP AEKARHLIKR QSNGIRSSRA ENSDLNSLIT
TAVAAAERLC IAIACSSNGE LWQFTCSPTG VKSNQVQLNI SSSSVSEGYP RSLIWRFSQG
LARESCWEFL MLTDCDIHCF TIEPYPDLTV SEVWQHEIVG TDGDSGIKKD IASQKQIWPL
DLQVDDQGKV ITVLVATICM DRASSSSYTQ YSLLTLQHKS EMRFADGREE KVLEKQGPIQ
VIIPKARVED KDFLFSMRLR VGGRPPGSAI ILSGDGTATV CYCHGSSTRL YKFDLPYDAG
KVLDASVLSS TDEHEYGAWT VLTEKAGVWA IPEKAVVLGG VEPPERSLSR KNSSNERSTR
DETRVTPYGV DRTAGRENSD IQNIEDKGNP KMGFTRQTAR DEESEALLGQ LFEGFLLSGK
VDGSLEKLSQ SGAFDRDGEA NVFARKSKSI VDTLAKHWTT TRGAEIVAMT VISSQLVEKQ
QKHENFLHFL ALSKCHEELC SKQRHSLQII LENGEKLAAM IQLRELQNMI NQNRSARFGS
PQAGSEDQVS CALWDLIQFV GERARRNTVL LMDRDNAEVF YSKVSELEEV FYCLNRQLEY
IIRADQPLGT QLQRACELSN ACVTILQTAL DYKNEHQMWY PPLEGLIPWH SQTVVCNGLW
CIASFMLHLL TEASRIDISA KSDIYTHLEV LTEVLLEACA GSTFAKLERE EENKGLLNEY
WTRRDTIFDS LYRQAKEFME AEIQGIRERT EATDEDIFRN RCSNLISIAK RHAGYKIMWK
ICYDLNDTGL LRNLMHEGVG PQGGFSYFVF QQLYDMKQFS KLLRLGEEFQ DELLIFLKRH
SDLVWLHQVF LHQFSSASDT LHTLALSQDE ESMTTVEERT GPEPEDVQPT FADRKRFLNL
SKIAYVADKD ADSESKVKRI EADLNLLKLQ EEITKALPNG EARNRLFRPE ELIETCLNIQ
GRWTAIKAFE VFAWTSSSFR ENHRSLLEEC WRNAADQDDW DRHHQASTNE GWSEEETLQN
LRNTALFQAS KRCYGPTRVN TFDGDFAQVL PLRRENPEDS TSSVEDVLMS HKDFAEAGKL
MLTAIMLGCV EEEGIVAEEF SSPME
