NU133_CAEEL
ID NU133_CAEEL Reviewed; 1129 AA.
AC P34343; Q5WRU8;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 4.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Nuclear pore complex protein 15;
DE AltName: Full=Nucleoporin npp-15;
GN Name=npp-15; Synonyms=nup133; ORFNames=C29E4.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12937276; DOI=10.1091/mbc.e03-04-0237;
RA Galy V., Mattaj I.W., Askjaer P.;
RT "Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit
RT of nuclear pore complex size exclusion in vivo.";
RL Mol. Biol. Cell 14:5104-5115(2003).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=16950114; DOI=10.1016/j.cub.2006.06.067;
RA Galy V., Askjaer P., Franz C., Lopez-Iglesias C., Mattaj I.W.;
RT "MEL-28, a novel nuclear-envelope and kinetochore protein essential for
RT zygotic nuclear-envelope assembly in C. elegans.";
RL Curr. Biol. 16:1748-1756(2006).
CC -!- FUNCTION: Important for early nematode development.
CC {ECO:0000269|PubMed:12937276}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:16950114}.
CC Nucleus, nuclear pore complex {ECO:0000269|PubMed:12937276}.
CC Note=Recruited early during nuclear envelope assembly after mitosis.
CC {ECO:0000269|PubMed:16950114}.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup133 family. {ECO:0000305}.
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DR EMBL; FO080706; CCD66018.1; -; Genomic_DNA.
DR PIR; S44772; S44772.
DR RefSeq; NP_498724.4; NM_066323.5.
DR AlphaFoldDB; P34343; -.
DR SMR; P34343; -.
DR BioGRID; 41321; 9.
DR STRING; 6239.C29E4.4; -.
DR iPTMnet; P34343; -.
DR EPD; P34343; -.
DR PaxDb; P34343; -.
DR PeptideAtlas; P34343; -.
DR PRIDE; P34343; -.
DR EnsemblMetazoa; C29E4.4.1; C29E4.4.1; WBGene00003801.
DR GeneID; 176114; -.
DR KEGG; cel:CELE_C29E4.4; -.
DR UCSC; C29E4.4; c. elegans.
DR CTD; 176114; -.
DR WormBase; C29E4.4; CE46384; WBGene00003801; npp-15.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00390000011529; -.
DR HOGENOM; CLU_277093_0_0_1; -.
DR InParanoid; P34343; -.
DR OMA; RYTLHHK; -.
DR OrthoDB; 51227at2759; -.
DR PhylomeDB; P34343; -.
DR Reactome; R-CEL-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-CEL-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-CEL-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-CEL-191859; snRNP Assembly.
DR Reactome; R-CEL-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-CEL-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-CEL-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-CEL-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-CEL-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-CEL-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:P34343; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003801; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000776; C:kinetochore; IMP:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; IDA:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; IDA:UniProtKB.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR007187; Nucleoporin_Nup133/Nup155_C.
DR InterPro; IPR014908; Nucleoporin_Nup133/Nup155_N.
DR InterPro; IPR037624; Nup133-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13405; PTHR13405; 1.
DR Pfam; PF03177; Nucleoporin_C; 1.
DR Pfam; PF08801; Nucleoporin_N; 1.
PE 3: Inferred from homology;
KW Developmental protein; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..1129
FT /note="Nuclear pore complex protein 15"
FT /id="PRO_0000204840"
SQ SEQUENCE 1129 AA; 128190 MW; 8DC884B295983965 CRC64;
MSGRDLELTL DRVSSIEYPA LVKEAFLNNW HASAHRSEVT SNCASLNDRY CWVLSRNQIF
IWERAKSSHR AIIPTQLPLP TSGLPRSVKC VVVYDGVHRG ANKTPCPGIL VVSPEGVLRH
WTSIESQTYI EEVLDINNEV ALRVELTDEP IDGKSASFLL TTTSGTVYFL NGKGQDSAKT
GALECNKVAG REAHGFRRRL SSIMFGGESK ESTSLITNSF QHQSKDLLVV TVSPDVLTVY
NMYTPCELWS LKTKEFFQPK IASFFEADLK RTPLKVRARL IDAAVFRDGL MILIGGTHEE
SQSVHMFMVW MSANWQTEQP TGVVWSARVP MNEHRALFSK IDDSIYSNLT LCIPKNTAES
KKADRTDGII IINPYFAVSL YLPFDLAKPK KPESLYRHVS IPPRDQLLGY AICSQYVYIM
MLESGVSTIR LLPRGFADSS IYTHEQVVVP SLSVGTDDWP ILSELLSEMV ASGLPKTPLY
QSLHRAFELF AEKHMAESEE ELKAIIKMPD QEIARIVSQF LYAIIDYSDA ANKTDTELHA
KRVLTSRIML FLKHMGVYER IISSPLGISR GGILSLRVGG TMLGEVSERV AASTAIWTWK
TSNETNSAVF DAIIEKVLRI PEVQDLGLKD KDALFGRCGL VHHIPVVAAQ QLEKNVIGKT
KSHRFEVFHA VCELLSGIKE TIISWRNCRT KVAIPKFPIW WTLETFASCY RDVAEKIIEE
LKNGSSTDSE RARLLMYILS IYDFYLSESD SQPDNDKVLQ EMIALGKPAD AMELAEKHKD
FGTLVKNYLT TDVGTRQKTF ERYKKMFEKD DFEMYLCDYL KEHGRNDVLL QQGGSRVDAY
LDNFKELRYS REIANKQFGK AALTLMSLAD AETKSFSKFV EFLTRAYYCA CSSIDGTDVS
EVLDFYKRRY PEMKHRKRIP TEILKICFGN DLDAMMSVED MLEWNMAVQP NDEASVEGFA
RAFHLLADLL AVHPDSDELK KKIDKTWKAL VDYDEWNRVR SKEDVEKKTI FGKFCNYLIN
SYPADKGDSF PIWMPISRRL IFPTDIDTVL DECIANTTGN HLSWIKGHLK WIGEQLCKQA
LLPKSAFFRP DMKQVGSISQ AALEAFGPIL QRREQRFIDQ LNRDSMMET
