NU133_DROME
ID NU133_DROME Reviewed; 1200 AA.
AC Q9VCW3; Q86PB8; Q961A9;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Nuclear pore complex protein Nup133 {ECO:0000305};
DE AltName: Full=133 kDa nucleoporin {ECO:0000312|FlyBase:FBgn0039004};
GN Name=Nup133 {ECO:0000303|PubMed:20547758};
GN ORFNames=CG6958 {ECO:0000312|FlyBase:FBgn0039004};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAO24981.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAO24981.1};
RC TISSUE=Larva {ECO:0000312|EMBL:AAO24981.1}, and
RC Pupae {ECO:0000312|EMBL:AAO24981.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAK93145.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1200.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAK93145.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAK93145.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=20547758; DOI=10.1128/mcb.00124-10;
RA Chen X., Xu L.;
RT "Specific nucleoporin requirement for Smad nuclear translocation.";
RL Mol. Cell. Biol. 30:4022-4034(2010).
CC -!- FUNCTION: Probable component of the nuclear pore complex (NPC)
CC (Probable). Plays a role in NPC assembly and/or maintenance
CC (PubMed:20547758). {ECO:0000269|PubMed:20547758, ECO:0000305}.
CC -!- SUBUNIT: Forms part of the Nup107-Nup160 subcomplex in the nuclear
CC pore. {ECO:0000250|UniProtKB:Q8WUM0}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q8WUM0}. Note=Located on both the cytoplasmic
CC and nuclear sides of the nuclear pore. {ECO:0000250|UniProtKB:Q8WUM0}.
CC -!- SIMILARITY: Belongs to the nucleoporin Nup133 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK93145.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF56042.2; -; Genomic_DNA.
DR EMBL; BT003226; AAO24981.1; -; mRNA.
DR EMBL; AY051721; AAK93145.1; ALT_INIT; mRNA.
DR RefSeq; NP_651080.2; NM_142823.3.
DR AlphaFoldDB; Q9VCW3; -.
DR SMR; Q9VCW3; -.
DR STRING; 7227.FBpp0083695; -.
DR PaxDb; Q9VCW3; -.
DR PRIDE; Q9VCW3; -.
DR DNASU; 42680; -.
DR EnsemblMetazoa; FBtr0084302; FBpp0083695; FBgn0039004.
DR GeneID; 42680; -.
DR KEGG; dme:Dmel_CG6958; -.
DR UCSC; CG6958-RA; d. melanogaster.
DR CTD; 55746; -.
DR FlyBase; FBgn0039004; Nup133.
DR VEuPathDB; VectorBase:FBgn0039004; -.
DR eggNOG; KOG4121; Eukaryota.
DR GeneTree; ENSGT00390000011529; -.
DR HOGENOM; CLU_008593_1_0_1; -.
DR InParanoid; Q9VCW3; -.
DR OMA; RYTLHHK; -.
DR OrthoDB; 51227at2759; -.
DR PhylomeDB; Q9VCW3; -.
DR Reactome; R-DME-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DME-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DME-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DME-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DME-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DME-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DME-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DME-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-DME-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR BioGRID-ORCS; 42680; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42680; -.
DR PRO; PR:Q9VCW3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039004; Expressed in eye disc (Drosophila) and 20 other tissues.
DR ExpressionAtlas; Q9VCW3; baseline and differential.
DR GO; GO:0031080; C:nuclear pore outer ring; ISS:FlyBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:FlyBase.
DR GO; GO:0006406; P:mRNA export from nucleus; ISS:FlyBase.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR007187; Nucleoporin_Nup133/Nup155_C.
DR InterPro; IPR014908; Nucleoporin_Nup133/Nup155_N.
DR InterPro; IPR037624; Nup133-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13405; PTHR13405; 1.
DR Pfam; PF03177; Nucleoporin_C; 1.
DR Pfam; PF08801; Nucleoporin_N; 1.
PE 2: Evidence at transcript level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT CHAIN 1..1200
FT /note="Nuclear pore complex protein Nup133"
FT /id="PRO_0000440691"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 135147 MW; DE2A38685CB2EA69 CRC64;
MERNLQKQLY GISRESSPGA RRYSMPAASA DSTRKSIFGG SASCAQMSGS LKRTALTNSR
LSLSVRSTQS IAGIRSDYNS VESFGCPLPV VVNEALTFAG PGAGTVTAKV TQNGWAWVVQ
GRRLLIWQYK DTAKSGSPPR VGKLARRGGG LAQCRELTLP YSDLGHKSDL ISVFQTEGQQ
MASCIAVSAT GEVRYWSSIA HDGNSVDLSI LTGQEFVQLL SLPTQQGYLA VTTTCNLVFL
RVGLTNGRYT LHHKTIKPAT SFLGGFGKKF ASILIGMNTG ADKDQTLVGM CCESNLESGE
TIVAVLSDRA IQRWSLSNNG NTENLLYEDA DMLRRIREEF ITNFWKFRLP ADSLEIDLHL
LDFHVVKNKA YILAGAVNAA HAPQMCYALV TGTAQAERML LESFTPLNMN KFFSAKTEED
CLSVRFVVGS SHIYLYTSKV VYPLHLTNSV PTAELEAEKI EFHQHDDRIL SAVICSQLPL
FFSRTHGLVS ITPGDFDGTE MMNMSSCNTP DLYAPNSCNA SFAVADHSAL TNSTNNLHLF
ELDPDEMYNE LSDEVGQLKA AFLYHMKRNS NMVKTIVDEL LRNVTAADPS GAPMDAYKLD
RIVITIAEDL AEDIPIADPR WEEALADQEM NRHAIGSSRS MQIINQLRDK IIAFQHFITF
LHSSLVWDKL NVIPCGSHSL KPTGCILADI SEKIVAAMAL RSIQTKLPKL IEEAIDATVA
LWHEEPQGSL TYQDIFYVKL SRFQNVFEAL ADIADDRIAA QNQTTISVAH FVNEINSIVL
DVLGQVFKYR KQHASSFRLS HEKLPSYENL PWTAMAGSAG VRDTLTRLID ISVRYGSHCV
SETELKQQLY QQIFELIDLV LDGRKTYLKS VRDTEKFNVL QQQFEAQRRE LISVLIKDRQ
YEYAAKIAEK YLDFQSLVLI CDETQDKERL EDYTRKYEEY DFSQFAINWH LRQNRHGEVF
ERFKGNQTAL AQFMRDHPSL GWIQLIFNGD FERAAKVLYE LAQCETEFVA RKKSMLSLAK
LAAFAAAESD LTAQVEKINA DLTLVEYQSQ LGHDVLESFG FDPAEQKVLK AEEIISLYIA
EENETASETE FRKALELLSY VEQPYDMRHK IWCAAIKRDN WTDYDPNNAV HYMQKLLFYK
IIEISQLMGN DSENVLPPME DFLESVELGD LPQQKPFQYL LKLTYEYVAD MFKQPDDMEL
