ID   NU146_SCHPO             Reviewed;        1325 AA.
AC   Q09847;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Nucleoporin nup146;
DE   AltName: Full=Nuclear pore protein nup146;
GN   Name=nup146; ORFNames=SPAC23D3.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15116432; DOI=10.1002/yea.1115;
RA   Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.;
RT   "Identification of genes encoding putative nucleoporins and transport
RT   factors in the fission yeast Schizosaccharomyces pombe: a deletion
RT   analysis.";
RL   Yeast 21:495-509(2004).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-899; THR-946; SER-1041;
RP   SER-1043 AND SER-1044, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. Active directional transport is assured by both, a Phe-Gly
CC       (FG) repeat affinity gradient for these transport factors across the
CC       NPC and a transport cofactor concentration gradient across the nuclear
CC       envelope. {ECO:0000269|PubMed:15116432}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear rim.
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DR   EMBL; CU329670; CAA91241.1; -; Genomic_DNA.
DR   PIR; S62497; S62497.
DR   RefSeq; NP_594543.1; NM_001019972.2.
DR   AlphaFoldDB; Q09847; -.
DR   SMR; Q09847; -.
DR   BioGRID; 278009; 2.
DR   IntAct; Q09847; 1.
DR   STRING; 4896.SPAC23D3.06c.1; -.
DR   iPTMnet; Q09847; -.
DR   MaxQB; Q09847; -.
DR   PaxDb; Q09847; -.
DR   PRIDE; Q09847; -.
DR   EnsemblFungi; SPAC23D3.06c.1; SPAC23D3.06c.1:pep; SPAC23D3.06c.
DR   GeneID; 2541507; -.
DR   KEGG; spo:SPAC23D3.06c; -.
DR   PomBase; SPAC23D3.06c; nup146.
DR   VEuPathDB; FungiDB:SPAC23D3.06c; -.
DR   eggNOG; KOG3630; Eukaryota.
DR   HOGENOM; CLU_257817_0_0_1; -.
DR   InParanoid; Q09847; -.
DR   OMA; GIPGQIE; -.
DR   PhylomeDB; Q09847; -.
DR   PRO; PR:Q09847; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR   GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR   GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR   GO; GO:0044613; C:nuclear pore central transport channel; ISO:PomBase.
DR   GO; GO:0044614; C:nuclear pore cytoplasmic filaments; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006407; P:rRNA export from nucleus; ISO:PomBase.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR039462; Nup159/Nup146_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF16755; NUP214; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Transport.
FT   CHAIN           1..1325
FT                   /note="Nucleoporin nup146"
FT                   /id="PRO_0000116418"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..951
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          973..994
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        759..779
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..860
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        936..950
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         899
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         946
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         1041
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         1043
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         1044
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   1325 AA;  145777 MW;  EEFD952FB7F0E6BD CRC64;
     MNAENTFSIL NTNEPNAGGS QVTESEIEEE DIEFLSFAAL KIGATSSLSN SSLGLPEYSN
     LFAINNLKSL FVAGVPNYLI IGSTLDLQKS LIDADENVDA NVLKDSASIR HVSLPDAKFS
     MVSFSSNGEF VIAYDFVSFE LSVYETDALL KNSATSIYKA VFPDLVQVLP NPEINNLVIL
     RNLKLEVFLL SLSKFQVESP LAKDATCAAW SRRGKQCVIG FNNGTMSQYT PAGEIKLRIP
     RPPSLENYFV ECISWIENRE FVVFYSPLTS LSNESDEPPH ESECFVISVG MNGHFNFGKA
     GDPTPPFGAV NRRDHHYIAS LHAWKPDLRS LVVVANTASA DLGVLALSME KNQWSILNIV
     DETKRASLPY SNKKDSDSSP TALVMDFTAT DRISKPLDPT EAPADCSPLP IVWVFNDEFQ
     LVAYRIFYAD AISKSIDYPE MNVIKDKNKD STVRASNNEN IPTPDKQASP FVKNLSSTSS
     PFSQSSAFGN FKFGQATSFD KGLSTDASSG AKSNTPVFGQ PSTFGQAPVF GQPSAFGQAP
     VFGQPSAFGQ SSFSFGTSNM NQKLDFGTFK SPLSGAATGE AKTNLEKAVT SASGKASFTG
     FAPSQSTTSG LNFDSIPKDN EAASIFGSSQ VSTKNTSGFQ FSNNTLLADN VDEDIESDHD
     TKIEELANSD VEPSTEQNIG GDVSWGASTF QSKPQPSFSF GLTLDDKSNT PGKNFSIFGK
     TAETQVEQKK PENNVLTKPF SFAPSDKSMF AANIPSAGEG LDQQKTSKAL PSTGITKLSE
     NDNEKAEESN ETKGFNTTIA KQNDKSSKSE GKASVANMSA LNKSTNNETS DSKPSLKSPL
     FNFSADAPTF TFNKPSETPP FSFNKPLVEK ESKQDVSDTS DRSPFSFKAF GIDSKKSPTP
     EPTEMAESNI SEESEGWKLI EQPNVESEIE DQDEESSDLN GKRRSTPPKI HEVGVNKMLD
     VVPKEKRDLN SFFPKQPLVV QSTDKNKKEP QESLEDEILS AEGFSEVEAA NKISRFEPFS
     SPKLKLATSD NAPEKYVFEE SESSDLEEGP VPLRNLESLA DLPEAESNEK LPMVNTFERL
     YLQFKNELDL VWQNINIIAE YIEGQTSTPS AVSEQATMAM LSQNTEELED LLDTVTSFSA
     FCSDYSKQID YLEACLVRIN AKRIQVTRLL KALTNPAFEK QMELRQLGPE ALRRQKELRL
     KMEKVLKSLS TLEQQAVDAR MSDTRRFKKP TLGSIEVAYS RIATLLGQRL KQLYKLEKDI
     KRMATKKKMI TKKSMSSDMM TQFRALGISQ SSTKQVSAHY LREFERQDAF RNGVFKRLTS
     LKKAD