NU170_CHATD
ID NU170_CHATD Reviewed; 1416 AA.
AC G0S7B6; G0ZGU4;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Nucleoporin NUP170 {ECO:0000303|PubMed:21784248};
DE AltName: Full=Nuclear pore protein NUP170;
GN Name=NUP170; ORFNames=CTHT_0036270;
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=759272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SUBUNIT.
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors. NUP170 probably plays an important role in NPC assembly and
CC organization. {ECO:0000250|UniProtKB:P38181}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC passive diffusion of ions and small molecules and the active, nuclear
CC transport receptor-mediated bidirectional transport of macromolecules
CC such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC subunits across the nuclear envelope. Due to its 8-fold rotational
CC symmetry, all subunits are present with 8 copies or multiples thereof.
CC Part of a tetrameric NUP192-NUP170-NIC96-NUP53 or NUP188-NUP170-NIC96-
CC NUP53 module. {ECO:0000250|UniProtKB:P38181,
CC ECO:0000269|PubMed:21784248}.
CC -!- INTERACTION:
CC G0S7B6; G0S156: NUP53; NbExp=12; IntAct=EBI-4325479, EBI-4325171;
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:P38181}. Nucleus membrane
CC {ECO:0000250|UniProtKB:P38181}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P38181}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P38181}. Nucleus membrane
CC {ECO:0000250|UniProtKB:P38181}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P38181}; Nucleoplasmic side
CC {ECO:0000250|UniProtKB:P38181}. Note=Symmetric distribution.
CC {ECO:0000250|UniProtKB:P38181}.
CC -!- SIMILARITY: Belongs to the non-repetitive/WGA-negative nucleoporin
CC family. {ECO:0000305}.
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DR EMBL; GL988041; EGS21760.1; -; Genomic_DNA.
DR EMBL; JF276286; AEL00682.1; -; Genomic_DNA.
DR RefSeq; XP_006694056.1; XM_006693993.1.
DR PDB; 5HAX; X-ray; 2.10 A; A=74-827.
DR PDB; 5HAY; X-ray; 2.80 A; A/B=832-1416.
DR PDB; 5HAZ; X-ray; 2.10 A; A=851-1416.
DR PDB; 5HB0; X-ray; 3.50 A; A/B/C/D=851-1402.
DR PDB; 5HB1; X-ray; 4.01 A; A=575-1403.
DR PDBsum; 5HAX; -.
DR PDBsum; 5HAY; -.
DR PDBsum; 5HAZ; -.
DR PDBsum; 5HB0; -.
DR PDBsum; 5HB1; -.
DR AlphaFoldDB; G0S7B6; -.
DR SMR; G0S7B6; -.
DR DIP; DIP-61836N; -.
DR IntAct; G0S7B6; 4.
DR STRING; 759272.G0S7B6; -.
DR TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR EnsemblFungi; EGS21760; EGS21760; CTHT_0036270.
DR GeneID; 18257665; -.
DR KEGG; cthr:CTHT_0036270; -.
DR eggNOG; KOG1900; Eukaryota.
DR HOGENOM; CLU_000429_0_1_1; -.
DR OrthoDB; 140051at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1880; -; 1.
DR Gene3D; 1.25.40.440; -; 1.
DR Gene3D; 1.25.40.450; -; 1.
DR InterPro; IPR007187; Nucleoporin_Nup133/Nup155_C.
DR InterPro; IPR014908; Nucleoporin_Nup133/Nup155_N.
DR InterPro; IPR004870; Nucleoporin_Nup155.
DR InterPro; IPR042533; Nucleoporin_Nup155_C_1.
DR InterPro; IPR042537; Nucleoporin_Nup155_C_2.
DR InterPro; IPR042538; Nucleoporin_Nup155_C_3.
DR PANTHER; PTHR10350; PTHR10350; 1.
DR Pfam; PF03177; Nucleoporin_C; 1.
DR Pfam; PF08801; Nucleoporin_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..1416
FT /note="Nucleoporin NUP170"
FT /id="PRO_0000433170"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 77..92
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 98..101
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 104..107
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 121..129
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 132..139
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 145..150
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 151..154
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 155..160
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 163..168
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 171..173
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 186..192
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 196..198
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 205..223
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 231..235
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 240..242
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 250..253
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 259..262
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 270..274
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 280..282
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 284..291
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 315..321
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 322..324
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 326..331
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 336..340
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 343..345
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 348..353
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 355..364
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 378..383
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 386..388
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 390..398
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 403..409
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 411..413
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 426..433
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 464..471
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 472..474
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 475..480
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 482..485
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 488..494
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 496..501
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 505..507
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 512..518
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 525..530
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 537..540
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 541..544
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 548..550
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 551..553
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 558..572
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 575..586
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 591..605
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 607..618
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 619..624
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 634..647
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 671..684
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 685..689
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 690..694
FT /evidence="ECO:0007829|PDB:5HAX"
FT STRAND 702..705
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 707..725
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 726..730
FT /evidence="ECO:0007829|PDB:5HAX"
FT TURN 732..734
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 748..779
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 782..787
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 791..798
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 802..807
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 809..824
FT /evidence="ECO:0007829|PDB:5HAX"
FT HELIX 852..867
FT /evidence="ECO:0007829|PDB:5HAZ"
FT TURN 868..870
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 872..888
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 889..892
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 895..907
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 911..924
FT /evidence="ECO:0007829|PDB:5HAZ"
FT TURN 925..928
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 930..937
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 946..970
FT /evidence="ECO:0007829|PDB:5HAZ"
FT STRAND 975..977
FT /evidence="ECO:0007829|PDB:5HAY"
FT HELIX 983..997
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1001..1014
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1017..1021
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1027..1036
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1040..1052
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1056..1067
FT /evidence="ECO:0007829|PDB:5HAZ"
FT STRAND 1069..1072
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1075..1088
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1098..1127
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1133..1143
FT /evidence="ECO:0007829|PDB:5HAZ"
FT STRAND 1144..1146
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1150..1156
FT /evidence="ECO:0007829|PDB:5HAZ"
FT TURN 1157..1162
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1164..1173
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1179..1208
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1227..1242
FT /evidence="ECO:0007829|PDB:5HAZ"
FT STRAND 1244..1246
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1251..1264
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1269..1271
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1277..1284
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1289..1302
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1309..1311
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1312..1333
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1353..1374
FT /evidence="ECO:0007829|PDB:5HAZ"
FT HELIX 1384..1406
FT /evidence="ECO:0007829|PDB:5HAZ"
FT STRAND 1412..1414
FT /evidence="ECO:0007829|PDB:5HAY"
SQ SEQUENCE 1416 AA; 156249 MW; 5C4DA7C530AA61AF CRC64;
MEPMTPMRPI PGAYVNTPAP PTANPARRRL FTEASSSGAA ATTQLGAAPA PLASTMAPGP
EINSGLMTPQ AREDLPPVAK AAQVVNQTLQ LDDSYPDLDS YCRPGASSDY EMQSSDSSWA
PFHVVRHHNI PDKVFEHLNA GEVFTKLGLF AEIGYAWASI DSSLFLWDYT HPNPELIGYE
EATHTITAVA LVPPKPGVFV KTITHVLVVA TTSEIILLGV SATPTPSGSK SLTLYSTRMS
VHRGGSDVSF IVGTKDGRIF LGGESDTDIH EIFYQQEERW FSSRCGKINH SHPGWSAVVP
SLAGLPFGSR QQEWLRGLYV DDTRNLLYSL SNRSTIRTYH MEGPEKLTKV IEKDKTSCLR
DFAHMADSSP LFTDKTNIVA LSPIPATEAS KLHLMALTDT GCRLFLSATS SASYTMGGAT
SLAPQSMQLQ FVKFPPRESP TRIRTLNGQI IDSQLDKTSR ALDPSALGFR FSPGYFFDVV
RKHPNQDMLF VSAPDTGRIK VTQPASALKY FEQGTWIELE NGNRTIEIGL TTAPFAAAKQ
PLGFGNELAV QFDQVPGEFA VLTNTGVHIV RRRRLVDIFA KALGNCVSAS DDALEREVRK
FINQYGRVET IAAALAVACG QGSDLRTGTG RGMDRNTENL ARAAFIEYGG QPRLAESDGK
QSVSESVRLS SRHDALALYL TRLVRTLWKA KVVQVGSGSD ISSTIPTSKL VTIQENVERL
RNFLEANKST IQGLAPPSER LFGRQEDIAN QKEHQALHAL QKLMESISEG ISFVLMLFDE
RVSDIYARLD AVSQQQLKDL TYEQLFSQTP GKELAKVLVK AIVNRNIASG ANVETVADAL
RRRCGSFCSP DDVVTFKAQE QLQRASEQAH NSPVLRALLA ESLRLFEQVA GSLTPANLTT
AVEQYISLKY YAGAIQLCLT VAQQKDRGNT ALSWVNDGKP ANDSRKKAFD ERKICYNLIH
QVLDKLESDF AGEPELVDGR PTLAATKRME AYNVVNDSSD EVFHFDLYEW YIEKGWTDRI
LSIDSPHVIT YLQRLAETDF RHAELLCRFY TTRSRFFEAA QVQTNLAKSD LNISLKDRII
LLSRAKGNAS VNTIGISRQQ QQQLNHEASE LLEIAHIQDD LLERLVADPR IPEERKAEIE
EFLDGPIRTL TDLFNDYADQ ANYYDLCLLI FHAADFHNPR TILDTWNNLI NQSHFEAEQR
REYWEIVQAG GDLPAGVIAP IAEPPLPYVY VSQQIQLIAH RTSLDSLIFP VNSLLPVVCA
YAINNGQDAS IGADPCWPIQ LFLNLGVPHA LVVQVLENVL DTQEAPFTGR RRKLVVQWIA
MAVDMWVREV ERRGAMAAAA ASGASGSEAV MGSWVSELLG RADQVLTQIA GTGATLRGGA
ASDAEEIASL RRTVKGLKRS VDMLLGGEMA RMSFFR
