ID   NU184_SCHPO             Reviewed;        1564 AA.
AC   Q9P7M8; Q9Y8G4;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Nucleoporin nup184;
DE   AltName: Full=Nuclear pore protein nup184;
GN   Name=nup184; ORFNames=SPAP27G11.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=10388805; DOI=10.1093/genetics/152.3.827;
RA   Whalen W.A., Yoon J.H., Shen R., Dhar R.;
RT   "Regulation of mRNA export by nutritional status in fission yeast.";
RL   Genetics 152:827-838(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Interacts with pom152 in the core structure of the nuclear
CC       pore complex (NPC). Involved in the export of mRNA.
CC       {ECO:0000269|PubMed:10388805}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000269|PubMed:10388805}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD43830.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF055035; AAD43830.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CU329670; CAB76031.1; -; Genomic_DNA.
DR   PIR; T43682; T43682.
DR   RefSeq; NP_593414.1; NM_001018847.2.
DR   AlphaFoldDB; Q9P7M8; -.
DR   SMR; Q9P7M8; -.
DR   BioGRID; 278264; 8.
DR   STRING; 4896.SPAP27G11.10c.1; -.
DR   MaxQB; Q9P7M8; -.
DR   PaxDb; Q9P7M8; -.
DR   EnsemblFungi; SPAP27G11.10c.1; SPAP27G11.10c.1:pep; SPAP27G11.10c.
DR   GeneID; 2541770; -.
DR   KEGG; spo:SPAP27G11.10c; -.
DR   PomBase; SPAP27G11.10c; nup184.
DR   VEuPathDB; FungiDB:SPAP27G11.10c; -.
DR   eggNOG; ENOG502QQFV; Eukaryota.
DR   HOGENOM; CLU_001029_0_0_1; -.
DR   InParanoid; Q9P7M8; -.
DR   OMA; KFFAIEH; -.
DR   PhylomeDB; Q9P7M8; -.
DR   Reactome; R-SPO-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-SPO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-SPO-3232142; SUMOylation of ubiquitinylation proteins.
DR   Reactome; R-SPO-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-SPO-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-SPO-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-SPO-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-SPO-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR   PRO; PR:Q9P7M8; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR   GO; GO:0044611; C:nuclear pore inner ring; IBA:GO_Central.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IGI:PomBase.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; ISO:PomBase.
DR   GO; GO:0006611; P:protein export from nucleus; ISO:PomBase.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR   InterPro; IPR018864; Nucleoporin_Nup188_N.
DR   InterPro; IPR044840; Nup188.
DR   InterPro; IPR041634; Nup188_C.
DR   PANTHER; PTHR31431; PTHR31431; 1.
DR   Pfam; PF10487; Nup188; 1.
DR   Pfam; PF18378; Nup188_C; 1.
PE   4: Predicted;
KW   mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   CHAIN           1..1564
FT                   /note="Nucleoporin nup184"
FT                   /id="PRO_0000204855"
FT   CONFLICT        1219
FT                   /note="S -> P (in Ref. 1; AAD43830)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1564 AA;  176964 MW;  248F3AEF338C30B7 CRC64;
     MGDYLLSWSW ILDAFETSDE NLSQNKFEEL LDARIAAFQQ IESPVTGTLN SNKTTEGEEA
     KLSIYDSSHS ISKSQLESVK KISDITGYNE AQVAYVLLVH QYELNTQYFS QLDNDSVLAQ
     EFQRRYYAEI ISCWKVLAFL LQACTDADSK WHKMATRLIV SIFQTAQRSG ENAQSTTPSI
     FCVRIIDYLS KMTSQAAPAS LTFNGEEAIS QWYFFHFNLQ LQLLRVIFLS TYSLVVCNSE
     MAISWFNCMK KTRYLHDQEF MHLDIDTGFS MCKEITNVAI IISINFISLE KQVLSFKDNP
     SFFMLSGNTI ISLHDMITQL SNDSIGAAVS LTWGIALHLL SNSPDNIPLI QNSSVVSSKI
     LQNPQNSFQA LIIAALKYDP FTLIHRIISS LEDDPYIDGY SKIMATLFSS AVSYVKFSDS
     TMLCATTLFK TPQVYQLFEN NDSVTRLLNF ARARFPFEYS QFVLLLIPTF ACLTSKQLVS
     SELLHMTTFT QSLPSGFKAY EIIPEPNVTG NALIELQESL HLDSYGFFFP NAERSLPKGT
     RGRIVSVDTY PPVVMWDLNY SLWEAVGISL NYIVRNGLIN SHKSFVLTVL SSSVPLFQTD
     VSGACELVHL ASEGLDGELD FINVICDLLD YFLSLSVIED ADYQICVSSL RLLREFTRFA
     ATDVWAYVTR SLVCVGSEKG ISLEDVIFDY ESINGVYDFT LAFFDLYEIL LDNCISTSVV
     PDDFSIRLKT DFVKRAMRFL CEVFANYLDW KYARIIQQYQ IGHRFASLIT KLLNVTFGIE
     YFNPKTTVNK KTLPLRELSH YIVQRFLVQQ DSNRYLHPLL SVMDLINLLY TDIFSTISSP
     RAKAAKMWLI SSFCAMKTLI CLRGFLNLKP SELERELFSR SPDLFNCLPR LLCCIAPILQ
     LLSALILAPW PSETPSLLAY MINSTDIVGR VCIQILTNPI QSTNIEGSVW KFLSSIMKGQ
     QQGLAVLLFS GKKFPLDRMK SLNHNVDVQL TSKSLISLAE KRLDSFSIND ILSQVPVFEF
     IFLSRNFWTA SLGNLQQEAN FWNRIVDAIK LPLTVKLDGL SSVAQADLYI LAAHATRITA
     IQLHMSKLNK SNSSKKIIID PLKDSMKDLV QHAFTITAYD SNIHNALTRA FKHENGDLHI
     SDLRNTGLFP LRYGDNYFYN IKLAKNMLLN TEDTSFKISM MMSANENLSL LDAQAALLRS
     WSIFICAFVE FVKEDATLSI LELKIMKWVL KSLAEDTIDV NVVQELSAER AALVFRISQQ
     TLAIPISNEV KEHLQSILLL TWKAITTTKF SIYEDSNGEM AYYRPLLHVL YNTLNRLLSE
     EKENLSLSVG FVSGLLQLCH RKLSQLFEKA VINPTIEVYG DIVLLNSLHK CIVNSHLIRG
     LQSLYISYIN DSFSVDNCLR LFSWSHSLLV DGQPYFADAA LSFLLICSSS PAGAEQIVMN
     GFFYSIMESP LSTALSTGGL GLDGSSIQYK IWIRGILPLL FNIVKFLGNR IMNDMREFVL
     LAFPQIQYAL LNWCQPPSSI SLASIDESFM IVLLFDLLQQ FNPALLQEIR LAELKIEMLE
     ASTI