ID   NU186_SCHPO             Reviewed;        1647 AA.
AC   P78847; Q1L847;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2000, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Nucleoporin nup186;
DE   AltName: Full=Nuclear pore protein nup186;
GN   Name=nup186; ORFNames=SPCC290.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1320-1647.
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15116432; DOI=10.1002/yea.1115;
RA   Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.;
RT   "Identification of genes encoding putative nucleoporins and transport
RT   factors in the fission yeast Schizosaccharomyces pombe: a deletion
RT   analysis.";
RL   Yeast 21:495-509(2004).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. Active directional transport is assured by both, a Phe-Gly
CC       (FG) repeat affinity gradient for these transport factors across the
CC       NPC and a transport cofactor concentration gradient across the nuclear
CC       envelope. {ECO:0000269|PubMed:15116432}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear rim.
CC   -!- SIMILARITY: Belongs to the NUP186/NUP192/NUP205 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA22873.1; -; Genomic_DNA.
DR   EMBL; D89197; BAA13858.1; -; mRNA.
DR   PIR; T41267; T41267.
DR   PIR; T42996; T42996.
DR   RefSeq; NP_588399.1; NM_001023390.2.
DR   AlphaFoldDB; P78847; -.
DR   SMR; P78847; -.
DR   BioGRID; 275337; 1.
DR   STRING; 4896.SPCC290.03c.1; -.
DR   MaxQB; P78847; -.
DR   PaxDb; P78847; -.
DR   EnsemblFungi; SPCC290.03c.1; SPCC290.03c.1:pep; SPCC290.03c.
DR   GeneID; 2538754; -.
DR   KEGG; spo:SPCC290.03c; -.
DR   PomBase; SPCC290.03c; nup186.
DR   VEuPathDB; FungiDB:SPCC290.03c; -.
DR   eggNOG; KOG1835; Eukaryota.
DR   HOGENOM; CLU_001071_0_0_1; -.
DR   InParanoid; P78847; -.
DR   OMA; WSQMFAE; -.
DR   PhylomeDB; P78847; -.
DR   Reactome; R-SPO-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-SPO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-SPO-3232142; SUMOylation of ubiquitinylation proteins.
DR   Reactome; R-SPO-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-SPO-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-SPO-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-SPO-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-SPO-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR   PRO; PR:P78847; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR   GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR   GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR   GO; GO:0044611; C:nuclear pore inner ring; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; ISO:PomBase.
DR   InterPro; IPR021827; Nup186/Nup192/Nup205.
DR   PANTHER; PTHR31344; PTHR31344; 1.
DR   Pfam; PF11894; Nup192; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Transport.
FT   CHAIN           1..1647
FT                   /note="Nucleoporin nup186"
FT                   /id="PRO_0000290670"
SQ   SEQUENCE   1647 AA;  186412 MW;  579B36CB5B5ED618 CRC64;
     MDVWESQHFS ALLYLLQCIE SNPSNPNVSS RLLIQCLESY SKDFLKFLAL DPANANSRKK
     LESGEVELGG VINKVNEQFI QLSLTLSTQL NLDEIQCASL LQRGIEASQN LDRTPVQAAL
     YFFFLAREQL LECLESLTRV VGLKDLESDI STALKSYLQS LCENGNNLVK TCIDTIPILD
     NKVSEILKSE AGGQILGVSE VVDFQEFIRL SHEAHVAELE TISVILYQLA KVDLFQNSHF
     ESLLVMLRKY DSPNKNAVLI LPTLYAFIDK VLEVEYLPDQ KVQLRSNSVE ILQKIHQAII
     QSPSQDWRSS QFKNILGIWW VTRLNATCKQ IEKVPSFIDY ETTIKNAANE IIQNGVFSDM
     ITLLVYPFRQ SETEGMEWAF AFKSRSRITV NWSLIRPFIA SIIFSELRSF AQAFVSYMPD
     ILKTLRLLEE DRYLTNTTYP TSIPGEQIEE YFPFEEFYYL LSSIYTYNVS WISDFWDDIE
     SDMYGFLTWS MGSQIPGIIT AFTLLLASLC KNTTSASKIY ELFSEPIPEV GHLESLMITS
     PSWSYIFNVF RYYISHLKPV QTVVTSSGLA RVHTDPSEID TDSALILQAY ILLFSSVVRQ
     DAQIASTFCE NQDLNPIATL FELLECRLPD SVRICIVRAL ESLAHLSTGS FNNALWTALD
     NWFVSSVLFD VDGGLAPMSI PAISKRSLTK PVTSCGPLLN NIRRLTVNLE MKISFVNLLT
     SLTRNKSELN VNLTFPENLG ASYRTPGVQP YVDYVVETFV ASSTQWRLMR DVGSIRLQYA
     CLQYMLAVLD GLNIDLLLYS RILSSKVRDN LQNNNLHVYL TRHPAISLLE ALYTESVYSG
     LFDLVEYGFD QLEDVSVPKT IVITVSASLC ILRNVLSLQR VLFKNVVPYI AELGISKYIL
     DLTISRRAYK EVFMTRISSI VHLALLVGSR HKCFLRSAIE ILSYLVDAEG FMNKRNPDEN
     KLLCSIIRTA NESKRIIFGF IRTFESQFLT LLSTNDESSL ILKLLLNNLK QSGGVYSLAL
     LILGFDISST NVITLRDQPG YVGSRVSLMN SLLDFIEGRT IVNGIWETPV IMVQALEIVA
     FLCSCPLTSE VTLSVIRARP GLLVKMVDGE PILTQQVIQN LGGFSSEEVS MVSRCIRSRT
     QIMNMLATEI HYAASVGQNK YLNEYVASLI RTNEKTHSTE LSQKESGFKI LEFMDILRID
     PQSITFELPN IPGFNLNMFI TRFDRGHSDF QFDTERVLKI YRLFFEAEMT SLGGSAEEKY
     SWLEQQNSKL KELAQRLNTF NAHVVLLQDI HGCLTAWARL TGLLVDDCNE VISDVHFDDF
     IWEVLRLVLP GVTVHNLGTQ GTVSVTSSVI ETILPHALRR IGALKPEELG KSTYFMEGIH
     DVIVGLLKGI QCQQSDESIR ENLYGSLLSI LTVFQKHTSA NGGDKVDPVF KDAFQKLITP
     NLLTSQFFDV LTKDALYTNG SCWELSVIIL NFLHHVSPDI STHLYKYYLR RNFVSSFIDA
     FSRAFSELLS SNKDVLEVLS GLEAGQCLLI TFAQNKLTVH SVLTFDYIKL MVQMLLQLCK
     QGGIQYLKPP VQRLMIQLLQ IFILVLMRVT LKEISNKDKL LLQSIFLLSR KLQDSVQTGA
     DQALSPEMNT VKKYVETISR LLDLYRD