NU188_MOUSE
ID NU188_MOUSE Reviewed; 1759 AA.
AC Q6ZQH8; Q4VA15; Q80UL4; Q8C7A1; Q8R3F1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Nucleoporin NUP188 {ECO:0000305};
GN Name=Nup188; Synonyms=Kiaa0169;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=B5/EGFP, FVB/N, and NMRI;
RC TISSUE=Mammary tumor, and Trophoblast stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-798.
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP PROTEIN SEQUENCE OF 1061-1070, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1719 AND SER-1727, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), a complex
CC required for the trafficking across the nuclear envelope. Required for
CC proper protein transport into the nucleus.
CC {ECO:0000250|UniProtKB:Q5SRE5}.
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC).
CC {ECO:0000250|UniProtKB:Q5SRE5}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q5SRE5}.
CC -!- SIMILARITY: Belongs to the Nup188 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH25526.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC97883.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129073; BAC97883.1; ALT_INIT; mRNA.
DR EMBL; AL954388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025526; AAH25526.1; ALT_INIT; mRNA.
DR EMBL; BC050199; AAH50199.1; -; mRNA.
DR EMBL; BC096591; AAH96591.1; -; mRNA.
DR EMBL; AK052272; BAC34911.1; -; mRNA.
DR CCDS; CCDS15878.1; -.
DR RefSeq; NP_938046.2; NM_198304.2.
DR AlphaFoldDB; Q6ZQH8; -.
DR SMR; Q6ZQH8; -.
DR BioGRID; 230667; 27.
DR ComplexPortal; CPX-4474; Nuclear pore complex.
DR IntAct; Q6ZQH8; 23.
DR MINT; Q6ZQH8; -.
DR STRING; 10090.ENSMUSP00000065836; -.
DR iPTMnet; Q6ZQH8; -.
DR PhosphoSitePlus; Q6ZQH8; -.
DR EPD; Q6ZQH8; -.
DR jPOST; Q6ZQH8; -.
DR MaxQB; Q6ZQH8; -.
DR PaxDb; Q6ZQH8; -.
DR PeptideAtlas; Q6ZQH8; -.
DR PRIDE; Q6ZQH8; -.
DR ProteomicsDB; 253036; -.
DR Antibodypedia; 34836; 89 antibodies from 13 providers.
DR DNASU; 227699; -.
DR Ensembl; ENSMUST00000064447; ENSMUSP00000065836; ENSMUSG00000052533.
DR GeneID; 227699; -.
DR KEGG; mmu:227699; -.
DR UCSC; uc008jcb.1; mouse.
DR CTD; 23511; -.
DR MGI; MGI:2446190; Nup188.
DR VEuPathDB; HostDB:ENSMUSG00000052533; -.
DR eggNOG; KOG4833; Eukaryota.
DR GeneTree; ENSGT00390000005742; -.
DR HOGENOM; CLU_002623_1_0_1; -.
DR InParanoid; Q6ZQH8; -.
DR OMA; KFMTIPE; -.
DR OrthoDB; 79804at2759; -.
DR PhylomeDB; Q6ZQH8; -.
DR TreeFam; TF101106; -.
DR Reactome; R-MMU-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-MMU-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-MMU-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-MMU-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-MMU-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
DR Reactome; R-MMU-191859; snRNP Assembly.
DR Reactome; R-MMU-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-MMU-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-MMU-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-MMU-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-MMU-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-MMU-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-MMU-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-MMU-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-MMU-5578749; Transcriptional regulation by small RNAs.
DR Reactome; R-MMU-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR BioGRID-ORCS; 227699; 22 hits in 72 CRISPR screens.
DR ChiTaRS; Nup188; mouse.
DR PRO; PR:Q6ZQH8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6ZQH8; protein.
DR Bgee; ENSMUSG00000052533; Expressed in spermatocyte and 179 other tissues.
DR ExpressionAtlas; Q6ZQH8; baseline and differential.
DR Genevisible; Q6ZQH8; MM.
DR GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR GO; GO:0005643; C:nuclear pore; IC:ComplexPortal.
DR GO; GO:0044611; C:nuclear pore inner ring; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IC:ComplexPortal.
DR GO; GO:0006606; P:protein import into nucleus; ISO:MGI.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR018864; Nucleoporin_Nup188_N.
DR InterPro; IPR044840; Nup188.
DR PANTHER; PTHR31431; PTHR31431; 1.
DR Pfam; PF10487; Nup188; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; mRNA transport;
KW Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport;
KW Reference proteome; Translocation; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5SRE5"
FT CHAIN 2..1759
FT /note="Nucleoporin NUP188"
FT /id="PRO_0000299173"
FT REGION 1255..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1508..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1718..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1729..1743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5SRE5"
FT MOD_RES 1719
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1727
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 798
FT /note="S -> R (in Ref. 4; BAC34911)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1759 AA; 196696 MW; 9067785281A0BF98 CRC64;
MAAAAGGPCV RSSRELWTIL LGRSALRELN QIEAELNKYW QRLLEGLSYY KPPSPSSAER
VKANKDVASP LKELGLRVSK FLGLDEEQSV QLLQCYLQED YRGTRDSLKT VLQDERQSQA
LTLKIADYYY EERTCILRCV LHLLTYFQDE RHPYRAEYAD CVDKLEKELV LKYRQQFEEL
YRTEAPTWET HGNLMTERQV SRWLVQCLRE QSMLLEIIFL YYAYFEMAPS DLLVLTKMFK
EQGFGSRQTS RHLVGGTMDP FVDRIGYFSA LILVEGMDIE SLHKYALDDR RELHQFAQDG
LICQDMDRAM LTLGDIPHHA PVLLAWALLR HTLSPEETSS VVRKIGGTAI QLNVFQYLTR
LLRSLASGGN DCTTSTACMC VYGLLSFALT SLELHTLGNQ QDVIDTACEV LADPSLPELF
WGTEPTSGLG IILDSVCGMF PHLLSPLLQL LRALVSGKST AKKVYSFLDK MSFYNELHKH
KPHDVLSHED GTLWRRQTPK LLYPLGGQTN LRIPQGTVGQ VMLDDRAYLV RWEYSYSSWT
LFTCEIEMLL HVVSTADVIQ HCQRVKPIID LVHKVISTDL SIADCLLPIT SRIYMLLQRL
TTVISPPVNV IASCVNCLTV LAARNPAKVW TDLRHTGFLP FVAHPVSNMT QMISAEGMNA
GGYGSLLMNS EQPQGEYGVT IAFLRLVTTL VKGQLGSTQS QGLVPCVMFV LKEMLPSYHK
WRYNSHGVRE LIGCLILELI HAILNLCQET ELHSSHTPSL PSLCICSLAY TEAGQTVISI
MGIGVDTIDM VMAAQPRSDG PEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA
LTQHGAHGNN LIAVLAKYIY HRHDPALPRL AIQLLKRLAT VAPMSVYACL GSDAAAIRDA
FLTRLQSKIE DMRIKVMILE FLTVAVETQP GLIELFLNLE VKDGSNGSKE FSLGVWSCLH
VVLELIDSQQ QDRYWCPPLL HRAAIAFLHA LWQDRRDSAM LVLRTKPKFW ENLTSPLFGT
LSPPSETSEP SVLETCALIM KIICLEIYYV VKGSLDQSLK DTLKKFSSEK RFAYWSGYVK
SLAVYMADTE GSSCTSLLEY QMLVSAWRIL LIIAASHADV MHLTDMAVRR QLFLDVLDGT
KALLLVAASV NCLRLGSMMC TLLLILLRQW KRELGAVEKI LGPLTEILEG VLQADQQLME
KTKAKVFSAF ITVLQMKELR VGDIPQYSQL VLNVCETLQE EVIALFDQTR HSLASDSAAE
DKDSMETDDC PRPRHKDQRD GVCVLGLHLA KELCEVDEDG DSWLQVTRRL PILPTLLTTL
EVSLRMKQNL HFTEAALHLL LTLARTQQGA TAVAGAGITQ SICLPLLSVY QLSSNGTGQT
PSTSRKSLDA PSWPGVYRLS MSLMERLLKT LRYNFLTEAL DFVGVHQERT LQCLNAVKTV
QSLACLEEAD HTVGFILQLS HFRKEWHFHL PQLMRDVQVN LGYLCQACTS LLHSRKMLQH
YLQNKNGDGL PSAVTPRAQR PSTTTTTTTT TTALATPAGC SSKQPTADTE ASEQRALHTV
QYGLLKILSR TLAALRHFTP DVCQILLDQS LDLAEYNFLF ALSFTTPTFD SEVAPSFGTL
LATVNVALNM LGELDKKKES LTQAVGLSTQ AEGTRTLKSL LMFTMENCFY LLISQAVRYL
RDPAVHPRDK QRMKQELSSE LSTLLSSLSR YFRRGAPSSP AAGVLPSPQG KATSLSKASP
ESQEPLIQLV QAFVRHVQR
