NU188_XENTR
ID NU188_XENTR Reviewed; 1739 AA.
AC F6WXT2; A9JRJ6;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Nucleoporin NUP188 {ECO:0000305};
GN Name=nup188;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=21282601; DOI=10.1073/pnas.1019645108;
RA Fakhro K.A., Choi M., Ware S.M., Belmont J.W., Towbin J.A., Lifton R.P.,
RA Khokha M.K., Brueckner M.;
RT "Rare copy number variations in congenital heart disease patients identify
RT unique genes in left-right patterning.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2915-2920(2011).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), a complex
CC required for the trafficking across the nuclear envelope. Required for
CC proper protein transport into the nucleus.
CC {ECO:0000250|UniProtKB:Q5SRE5}.
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC).
CC {ECO:0000250|UniProtKB:Q5SRE5}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q5SRE5}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing kidney at stages 26-29
CC and 33-36, and in the branchial arches at stage 33-36.
CC {ECO:0000269|PubMed:21282601}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes
CC abnormal heart and gut looping. {ECO:0000269|PubMed:21282601}.
CC -!- SIMILARITY: Belongs to the Nup188 family. {ECO:0000305}.
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DR EMBL; AAMC01047074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC155686; AAI55687.1; -; mRNA.
DR RefSeq; NP_001107292.1; NM_001113820.1.
DR AlphaFoldDB; F6WXT2; -.
DR SMR; F6WXT2; -.
DR STRING; 8364.ENSXETP00000028229; -.
DR PaxDb; F6WXT2; -.
DR GeneID; 100135081; -.
DR KEGG; xtr:100135081; -.
DR CTD; 23511; -.
DR Xenbase; XB-GENE-5933085; nup188.
DR eggNOG; KOG4833; Eukaryota.
DR HOGENOM; CLU_002623_1_0_1; -.
DR InParanoid; F6WXT2; -.
DR OMA; KFMTIPE; -.
DR OrthoDB; 79804at2759; -.
DR TreeFam; TF101106; -.
DR Reactome; R-XTR-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-XTR-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-XTR-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-XTR-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-XTR-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-XTR-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-XTR-5578749; Transcriptional regulation by small RNAs.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0044611; C:nuclear pore inner ring; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR018864; Nucleoporin_Nup188_N.
DR InterPro; IPR044840; Nup188.
DR PANTHER; PTHR31431; PTHR31431; 1.
DR Pfam; PF10487; Nup188; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..1739
FT /note="Nucleoporin NUP188"
FT /id="PRO_0000425795"
FT REGION 1249..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1506..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 124..125
FT /note="Missing (in Ref. 2; AAI55687)"
FT /evidence="ECO:0000305"
FT CONFLICT 1568
FT /note="Q -> QVQ (in Ref. 2; AAI55687)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1739 AA; 195331 MW; D712DA22F279D36D CRC64;
MAAAGCLYRR TSRELWTILL GRSSMKDGHQ IKAELDRYGD RLLQGLAYYR PPSTSSTGKV
KANKNLSPAL QELGLRLSKF LGLDEEQSVE LLQTYLLYDY RGTQESVKGV PQDERQSQAL
MLKASMVDYY YEERISLLRC VLYILNYFQD DKHPYSAEFS KCVEMMEQKE LFGKYLKQFE
SLCREEAPTW ETHGNFMTER QVSRWFVQRL REQAMLLEII FLYFACFAAS PSDLLALTKL
FKEQGFGCRL QNRHLVEPSM DPLVERIGYF SVLIFLEALD IETLMTCSLS DKTEQHPFSS
EEQVCKEMDS VLVTLGDAPH HGPVLLAWAL LRFALNADKV TPTVRKMGST AIQLHIFQYL
TRMLQSLRSG ENNCTTSTAC LCVYTFLTFV LTNLEEQVLQ SQQDLVDTAF QVFAAPNLPD
LFWNMEPTAG LGILLDSVVG MFPFHLSPLL KLFTALVSKS SAKKVYSFLD RMSSYTEHYR
HKPHDILSHE DETLWKRQTP KVLYALGLGQ TNLRIPQGTI GQVMADEHGF LVRWEYSYSC
WTLFTCEIEM LLHVVSTADV IHQCQRVKPI IDLVHKVIST DLSIADCLLP ITSRIYMLLQ
RLTTVMNPPM DFLSSCVDCL AALATRMPAK VWIDLRHTGF LPFAANPVSG HIISTEGMNA
GGYGSLFGIE QSQGEYSITL SFLRLVTTLV KGQLGSTQSQ GLVPCILFVL REMLPNYHRW
RYNSHGVREQ LGFQILSLIH AILNLSPEEE ESTSTPNLQS LCIFSLTNTE AGQAVINIMG
VGVDTLNAVM LTQAGSSGTE GQGQMLMQTI KLAFSITNNV IRLKPLSSAI SPLEHALTQH
GAHGNNLIAV LAKYIYHKYD PSLPRLAIQL LKRLAMVAPM SVYACLGSDA AAIRDAFLSR
LRDNIEDMQI KIMILEFLTV AVETQPGLIE LFLNLEVKDT NEGSKEYSLG EWSCLQVVLK
LIDSQDPESS WGAPLLHRSA IAFLHALWQD RRDSAMTVLR TKPNFWENLT SPLFGTLAFP
SESSELSILE TCAFIMKIIC LEIYYAVRGS LGDSLKKILK KFSEEERFTY WSNYVHSLVC
QVAESEGACN SLTEYQQLLS AWRMFLMVAT HNADVMHLTN PEVRQKLFKD VLGGTQALLL
VPRSMTCLHL GSMLCTVMII LLRRWKSDLA APEDILSSLT QILEGVLQKD QQLVEKTKAR
VFAALISALE IKPMKASEIP QYPQLVLNVC ETLQEEVVFL VDHTRQEVPA NDASEDKDSM
ETEDTGRIRQ KDQRDGVCVL GLHLAKGLCE ADEEGDQWQQ VLRKLPVLPM LFSALEVSLR
IKQNLHFCEA ILHFLFTLAK THQGAAAMAG AGVTQTVCLP LLSVYQLSSN GASTAQPALS
LRKSLDAPSW PGVYRLTVSL MERLLKTLRY NFLTEALDFV GVHQERILQC LGAVRTVPSL
ACLEEADHTV GFLLQLSNFT KEWHFHLPQL IKDVQVNLCY LCQACTSLLH SRKMLQHYLQ
IKNGETMSST ATPRGQRTPQ TPSKQPTAES EALELRQLRS VQHSLLKILG KTLATLRAFT
PDLCQILQPL DLAQYNLLFA LSFTTPAFDA DVTPSFGTLL ATVNVTLSML GEMDKKKDHP
LGQVLGETNS TVDNKNIKSL LLFIMENCFY LLISQAVRYL RDPSVHPRDK QRMKQELSSE
LSTLLSSLSR YFRRGGPSSP AGGLMPSPQP KGASAAKVVP EAQEPLIQLV QAFVRHVQR
