NU192_CHATD
ID NU192_CHATD Reviewed; 1756 AA.
AC G0S4T0; G0ZGU6;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Nucleoporin NUP192 {ECO:0000303|PubMed:21784248};
DE AltName: Full=Nuclear pore protein NUP192;
GN Name=NUP192; ORFNames=CTHT_0023410;
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=759272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SUBUNIT.
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 1-958.
RX PubMed=24505056; DOI=10.1073/pnas.1311081111;
RA Stuwe T., Lin D.H., Collins L.N., Hurt E., Hoelz A.;
RT "Evidence for an evolutionary relationship between the large adaptor
RT nucleoporin Nup192 and karyopherins.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:2530-2535(2014).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors. NUP192 is located to the NPC core at the nuclear membrane and
CC is essential for de novo assembly of NPCs.
CC {ECO:0000250|UniProtKB:P47054}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC passive diffusion of ions and small molecules and the active, nuclear
CC transport receptor-mediated bidirectional transport of macromolecules
CC such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC subunits across the nuclear envelope. Due to its 8-fold rotational
CC symmetry, all subunits are present with 8 copies or multiples thereof
CC (By similarity). Part of a tetrameric NUP192-NUP170-NIC96-NUP53 module.
CC {ECO:0000250|UniProtKB:P47054, ECO:0000269|PubMed:21784248}.
CC -!- INTERACTION:
CC G0S4T0; G0S024: NIC96; NbExp=7; IntAct=EBI-4325187, EBI-4325173;
CC G0S4T0; G0SAK3: NUP145; NbExp=3; IntAct=EBI-4325187, EBI-16069276;
CC G0S4T0; G0S156: NUP53; NbExp=13; IntAct=EBI-4325187, EBI-4325171;
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:P47054}. Note=Cytoplasmic and nucleoplasmic side
CC of the nuclear pore complex in the nuclear envelope (symmetric
CC distribution). {ECO:0000250|UniProtKB:P47054}.
CC -!- SIMILARITY: Belongs to the NUP186/NUP192/NUP205 family. {ECO:0000305}.
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DR EMBL; GL988041; EGS20509.1; -; Genomic_DNA.
DR EMBL; JF276288; AEL00684.1; -; Genomic_DNA.
DR RefSeq; XP_006692805.1; XM_006692742.1.
DR PDB; 4KNH; X-ray; 2.70 A; A/B=1-958.
DR PDB; 5CWV; X-ray; 3.15 A; A/B=1397-1756.
DR PDB; 5HB4; X-ray; 3.20 A; B=151-166, B=185-1756.
DR PDBsum; 4KNH; -.
DR PDBsum; 5CWV; -.
DR PDBsum; 5HB4; -.
DR AlphaFoldDB; G0S4T0; -.
DR SMR; G0S4T0; -.
DR DIP; DIP-61834N; -.
DR IntAct; G0S4T0; 6.
DR STRING; 759272.G0S4T0; -.
DR TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR EnsemblFungi; EGS20509; EGS20509; CTHT_0023410.
DR GeneID; 18256379; -.
DR KEGG; cthr:CTHT_0023410; -.
DR eggNOG; KOG1835; Eukaryota.
DR HOGENOM; CLU_002778_0_0_1; -.
DR OrthoDB; 90119at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR021827; Nup186/Nup192/Nup205.
DR PANTHER; PTHR31344; PTHR31344; 1.
DR Pfam; PF11894; Nup192; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..1756
FT /note="Nucleoporin NUP192"
FT /id="PRO_0000433168"
FT HELIX 6..21
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 28..37
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 39..44
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 53..61
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 64..68
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 71..74
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 77..90
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 94..107
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 109..112
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 117..143
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 150..163
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 185..217
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 225..251
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 257..269
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 275..291
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 293..296
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 300..303
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 305..310
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 314..316
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 322..336
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 337..340
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 343..346
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 353..369
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 372..383
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 391..393
FT /evidence="ECO:0007829|PDB:4KNH"
FT TURN 394..397
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 416..436
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 438..454
FT /evidence="ECO:0007829|PDB:4KNH"
FT TURN 456..459
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 463..475
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 479..486
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 492..500
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 506..517
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 523..533
FT /evidence="ECO:0007829|PDB:4KNH"
FT TURN 545..547
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 552..567
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 593..612
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 614..621
FT /evidence="ECO:0007829|PDB:4KNH"
FT TURN 624..626
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 628..637
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 642..654
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 661..676
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 701..712
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 716..729
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 736..738
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 747..753
FT /evidence="ECO:0007829|PDB:4KNH"
FT STRAND 756..758
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 759..770
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 772..775
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 779..798
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 802..810
FT /evidence="ECO:0007829|PDB:4KNH"
FT TURN 811..814
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 821..830
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 833..840
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 843..853
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 857..862
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 868..891
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 894..905
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 920..924
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 928..937
FT /evidence="ECO:0007829|PDB:4KNH"
FT TURN 938..941
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 943..956
FT /evidence="ECO:0007829|PDB:4KNH"
FT HELIX 962..964
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 978..985
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 989..1001
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 1006..1010
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1013..1030
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1038..1042
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 1059..1063
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1066..1074
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1088..1106
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1108..1120
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1123..1130
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1156..1176
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 1177..1181
FT /evidence="ECO:0007829|PDB:5HB4"
FT STRAND 1182..1184
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1186..1197
FT /evidence="ECO:0007829|PDB:5HB4"
FT STRAND 1202..1206
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 1213..1215
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1226..1228
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1234..1239
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1258..1275
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1281..1327
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1333..1353
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 1354..1356
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1358..1372
FT /evidence="ECO:0007829|PDB:5HB4"
FT TURN 1397..1400
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1401..1413
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1418..1433
FT /evidence="ECO:0007829|PDB:5CWV"
FT TURN 1434..1436
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1457..1471
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1473..1483
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1488..1504
FT /evidence="ECO:0007829|PDB:5CWV"
FT TURN 1505..1508
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1521..1528
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1531..1537
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1538..1541
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1542..1547
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1573..1587
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1590..1598
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1601..1608
FT /evidence="ECO:0007829|PDB:5CWV"
FT STRAND 1610..1613
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1628..1651
FT /evidence="ECO:0007829|PDB:5CWV"
FT TURN 1655..1657
FT /evidence="ECO:0007829|PDB:5HB4"
FT HELIX 1658..1667
FT /evidence="ECO:0007829|PDB:5CWV"
FT TURN 1668..1670
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1671..1676
FT /evidence="ECO:0007829|PDB:5CWV"
FT TURN 1704..1707
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1708..1731
FT /evidence="ECO:0007829|PDB:5CWV"
FT TURN 1732..1734
FT /evidence="ECO:0007829|PDB:5CWV"
FT HELIX 1735..1739
FT /evidence="ECO:0007829|PDB:5CWV"
SQ SEQUENCE 1756 AA; 196928 MW; E8FB491DE3F6FCDB CRC64;
MTDLRKLEAL QALHAELVAV RQHRFEGLQV LETLLEEQTD AFKALIAKPA RDTKDREALG
KEPKKLKIGE EEYSLNEDFV NDCLKLADEL DLNEKESARI LIDCDAEGDV ETQSRPLWEC
GVIRFHQERK YLLDCMRLIL EIAADEDIDA GLQESFGVAA EDKIFGIPPP WERNKENQPT
QVKKFIPRCM EAMKGVRSML QCMADKANAR NMLQQASLVR PLDNQETLDF SRLSLVEQHE
CLASILHAAV QRHHATIADF QDFIKILRKW DKYDHFLIHL IPVLAAYITE FGSPEGMGDL
QQARRLNDFI CKGGDEDSWA LPVLGAAVRA WWIAEHNGFY LDDTVQDLRG INLDEEDEQR
TKQFLDALKE GAFDFILSVA ADCKAQEWQD PSQLGARQWL QRKIPSLPSE PFPFSHFLQH
SLMVHLEGFV DATISNLPDV LRKLRTEEDE QRQLRPNHEQ DMDLERFLII ISYAYEGRPD
AAMSFWEDPD SNLAGFLQWA SRRASTPLVS AFCEMLRCLA DNEECATAAH NFLLDEGHQA
SGKMKRSQSL TWSQIFKELE YFTTKVCSER PNPPQASMHR PGRPGADPAE IEPESALMLE
CYLRLIAKLA TESEIARKRL IMDEDFNLVD TILKLSVGVI PHRLRACIFY VLKALMIRKT
HEELDAMWRW VEAWMTNPFS SLPGSQGAPQ RISFLGQTPG PQECMEMMFR EFGTGFEQSN
AFIQLLTTLL VPPEGLNSLN DSVPFPEWLG SSIRTLGIEP YVDFVFDVFA NRTKDISDPS
QLRILRLSCL DFVMVCLVTF NEDLIVLGHE SNISIDDAMA ATNLATYVRL HPFSRVMEWL
FNEKVITSLI NTIHQDPISL GSASPDSPLV VSILRAIQVM IKALELQETY LHLVRPEVLR
YQGEAGVRRK PVANAAYSAF EDGILSHLSL VVDLGKYCNL GHAELTLACL KLLEKISTSS
RILSAWSPDS GRLGHRNKAI VQLERNGEGE TISASLSASI MATLDPALAA SGENYRVKLA
ILDFLYACLR ATPDQPTIAH QLLGFHCELS KLGIEPKGPF DMQKSLFHSL LNVLITLTVS
EEEQGMRGYL VTLKYRVLRI LQLLWKSPLS ASLVMDELRA TNFLFHMLLR EVQIQPQLPW
DGQLVTGCEF LLSDASLAYI DYLASRAAIF EYIGKELCSV SQNRIPSIKR QIFDALNGQI
FVDEEAPLTI PSIFDFFDFI NTDYKWEEIP SPHFTYLKDL DLGPCILEHK YAGVHYDIRK
AQEILALKRK EYEHSQLATP EFLETVELEE KVLIEWLTVR NRANLLLTAR LNLLQAWANL
LLVMIESNDF KSTPKMAFLL QALQAILPTL EAFSSLKSDE AFELARVAKV LLWKLDFSQD
SDAGLDREQF TVGNLIGDKL FQLFQLCLSA ISQCSGTPEL RSLYYSICYR YLTAVVDNDA
TVAATPASST IGPTRSVTNA RARTLKAITL YGDRLLNVIC DDAYGSDTTC QTAAMILLNA
LVHTSRASSA AGVSPADVDC PIIDALNRLN FIGVLVDSLK EILNEWLAPS STFDPSLSTN
ASPSLPIPAS PSQQYTSAKL ALLLQLCQTR QGAKYVLQAN LFRALEQSGV FAADPELVEV
DSESGVPRVV ALERHYALLV ALARVVGAAV TARGAHNIVQ GRKFLTQHRG LVVHVLKKNA
GIGGGVVGNS LASSINGGST ATMTRRDEIL AQQALEERIE ELAEAFMLLI TATGFLEYES
EQVPSEQPRA HTTFFH
