ID   AROK_THEGJ              Reviewed;         273 AA.
AC   C5A784;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Shikimate kinase {ECO:0000255|HAMAP-Rule:MF_00370};
DE            Short=SK {ECO:0000255|HAMAP-Rule:MF_00370};
DE            EC=2.7.1.71 {ECO:0000255|HAMAP-Rule:MF_00370};
GN   Name=aroK {ECO:0000255|HAMAP-Rule:MF_00370}; OrderedLocusNames=TGAM_1594;
OS   Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=593117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15229 / JCM 11827 / EJ3;
RX   PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA   Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA   Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT   "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT   the most radioresistant organism known amongst the Archaea.";
RL   Genome Biol. 10:R70.1-R70.23(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + shikimate = 3-phosphoshikimate + ADP + H(+);
CC         Xref=Rhea:RHEA:13121, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36208, ChEBI:CHEBI:145989, ChEBI:CHEBI:456216;
CC         EC=2.7.1.71; Evidence={ECO:0000255|HAMAP-Rule:MF_00370};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       5/7. {ECO:0000255|HAMAP-Rule:MF_00370}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00370}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Archaeal shikimate
CC       kinase subfamily. {ECO:0000255|HAMAP-Rule:MF_00370}.
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DR   EMBL; CP001398; ACS34096.1; -; Genomic_DNA.
DR   RefSeq; WP_015859207.1; NC_012804.1.
DR   AlphaFoldDB; C5A784; -.
DR   SMR; C5A784; -.
DR   STRING; 593117.TGAM_1594; -.
DR   PaxDb; C5A784; -.
DR   EnsemblBacteria; ACS34096; ACS34096; TGAM_1594.
DR   GeneID; 7988488; -.
DR   KEGG; tga:TGAM_1594; -.
DR   PATRIC; fig|593117.10.peg.1598; -.
DR   eggNOG; arCOG01025; Archaea.
DR   HOGENOM; CLU_073768_0_0_2; -.
DR   OMA; WDVLVWT; -.
DR   OrthoDB; 98200at2157; -.
DR   UniPathway; UPA00053; UER00088.
DR   Proteomes; UP000001488; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004765; F:shikimate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   HAMAP; MF_00370; Shik_kinase_arch; 1.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR010189; SK_arc.
DR   PANTHER; PTHR20861:SF3; PTHR20861:SF3; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF005758; Shikimt_kin_arch; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   TIGRFAMs; TIGR01920; Shik_kin_archae; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; ATP-binding;
KW   Cytoplasm; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN           1..273
FT                   /note="Shikimate kinase"
FT                   /id="PRO_1000205580"
FT   BINDING         85..95
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00370"
SQ   SEQUENCE   273 AA;  28819 MW;  CA598AF46B623BD2 CRC64;
     MRGYGRAGSA VTVVNAFATG KGGAVGIDLW TEAKVKLVED GISGSITVRG ESFGDTRLVR
     AVVEVVRRAT GEDFGIEFEI SSEIPVGKGL KSSSAAANAL VLAIYEALGI EIAPLEAIKL
     GVEAARLAGV TITGAFDDAS ASLLGGLCLT DNTRDELLKR EEVEPEPVVL LIPEESIMTS
     SLKGMDFSGI APYITEAFDM AMRGEWRKAL VINGLVYSAF LGHPTEPIGT ALRLGAIAGL
     SGKGPAFFAL TREPEVLSEE WSRFGKTEIT KLR