ID   NU1M_AEDAE              Reviewed;         313 AA.
AC   B0FWD8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000250|UniProtKB:P03887};
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1 {ECO:0000250|UniProtKB:P03887};
GN   Name=mt:ND1 {ECO:0000250|UniProtKB:P18929};
GN   Synonyms=ND1 {ECO:0000312|EMBL:ABY51635.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OG   Mitochondrion {ECO:0000312|EMBL:ABY51635.1}.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:ABY51635.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12 {ECO:0000312|EMBL:ABY51635.1};
RA   Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V.,
RA   Severson D.W.;
RT   "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250|UniProtKB:P03887}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000255}.
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DR   EMBL; EU352212; ABY51635.1; -; Genomic_DNA.
DR   RefSeq; YP_001649174.1; NC_010241.1.
DR   AlphaFoldDB; B0FWD8; -.
DR   SMR; B0FWD8; -.
DR   STRING; 7159.AAEL018687-PA; -.
DR   VEuPathDB; VectorBase:AAEL018687; -.
DR   eggNOG; KOG4770; Eukaryota.
DR   HOGENOM; CLU_015134_0_1_1; -.
DR   InParanoid; B0FWD8; -.
DR   OrthoDB; 1214989at2759; -.
DR   Proteomes; UP000008820; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..313
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000347267"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  36146 MW;  CC09B29B76B1BC04 CRC64;
     MDYLLSLIGS LLLVICVMVG VAFLTLLERK VLGYIQIRKG PNKVGFMGLL QPFSDAVKLF
     TKEQTYPLLS NYIFYYFSPI FSLFLSLLIW MSMPYLIKLY SFNLGVLFFL CITSLGVYTV
     MVAGWSSNSN YALLGGLRAV AQTISYEVSL ALILLSFIFL IGNYNFLNFF MYQKYMWFIV
     FCFPLGLVWF ASCLAETNRT PFDFAEGESE LVSGFNVEYS SGGFALIFLA EYSSILFMSM
     LFSVIFLGSD IYSILFFFKL TIISFFFIWV RGTLPRFRYD KLMYLAWKSF LPMSLNYLFF
     FIGVKIFILS MLF