NU1M_ANAPL
ID NU1M_ANAPL Reviewed; 117 AA.
AC P50658;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
DE Flags: Fragment;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Anas platyrhynchos (Mallard) (Anas boschas).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Pekin breed; TISSUE=Liver;
RX PubMed=8230253; DOI=10.1007/bf00175506;
RA Ramirez V., Savoie P., Morais R.;
RT "Molecular characterization and evolution of a duck mitochondrial genome.";
RL J. Mol. Evol. 37:296-310(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 86-117.
RC STRAIN=Pekin breed; TISSUE=Liver;
RX PubMed=2390786; DOI=10.1007/bf00313080;
RA Desjardins P., Ramirez V., Morais R.;
RT "Gene organization of the Peking duck mitochondrial genome.";
RL Curr. Genet. 17:515-518(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; L22479; AAA16539.2; -; Genomic_DNA.
DR EMBL; X55528; CAA39145.1; -; Genomic_DNA.
DR AlphaFoldDB; P50658; -.
DR SMR; P50658; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..>117
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117340"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_TER 117
SQ SEQUENCE 117 AA; 12902 MW; FEDD1E869D692740 CRC64;
MPQTTMVSYL IMALLYIIPI LIAVAFLTLV ERKILSYMQS RKGPNIVGPF GLLQPIADGI
KLFIKEPIRP STSSPLLFIM MPMLALLLAL TAWVPLPLPF SLVDLNLGVL FMVAMSS