NU1M_ARTSF
ID NU1M_ARTSF Reviewed; 298 AA.
AC Q37714;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ND1; Synonyms=ND-1;
OS Artemia franciscana (Brine shrimp) (Artemia sanfranciscana).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Anostraca; Artemiidae; Artemia.
OX NCBI_TaxID=6661;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8169960; DOI=10.1007/bf00166162;
RA Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.;
RT "Speciation in the Artemia genus: mitochondrial DNA analysis of bisexual
RT and parthenogenetic brine shrimps.";
RL J. Mol. Evol. 38:156-168(1994).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; X69067; CAA48818.1; -; Genomic_DNA.
DR PIR; S60649; S60649.
DR RefSeq; NP_007120.1; NC_001620.1.
DR AlphaFoldDB; Q37714; -.
DR SMR; Q37714; -.
DR GeneID; 807793; -.
DR CTD; 4535; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..298
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117347"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 298 AA; 33763 MW; 07FED8CD6219E11E CRC64;
MIYFIFLQVV MVLVSVAFLT LLERKILGYI QLRKGPNKVG FLGILQPFSD GVKLFCKEVS
LPLVSNFMPY LVAPVFSLFL SFFLWTLVPF ISYGAKFNLS FLLVICAMSV SVYSIMVAGW
SSNSKYSLLG SIRAGAQTIS YEVSLIIIIL SPLMLFKKLD LEGYLVKSSY VGWPLYLCLP
LGLCWFTTIL AETNRTPFDL AEGESELVSG FNTEYMGVGF ALIMLSEYAS ILFMSLLFSV
VFGSMSFLMF CLVVYSYLWS RGSYPRYRYD NLMHLCWKSL LPTSLMFLCF YWSLSQGG
