ID   NU1M_BRAFL              Reviewed;         313 AA.
AC   P69234; O21000; O47433;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1; Synonyms=NAD1, NADH1;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000312|Proteomes:UP000001554};
RX   PubMed=10331267; DOI=10.1093/oxfordjournals.molbev.a026122;
RA   Boore J.L., Daehler L.L., Brown W.M.;
RT   "Complete sequence, gene arrangement, and genetic code of mitochondrial DNA
RT   of the cephalochordate Branchiostoma floridae (Amphioxus).";
RL   Mol. Biol. Evol. 16:410-418(1999).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF098298; AAB88002.1; -; Genomic_DNA.
DR   RefSeq; NP_007768.1; NC_000834.1.
DR   AlphaFoldDB; P69234; -.
DR   SMR; P69234; -.
DR   GeneID; 808737; -.
DR   KEGG; bfo:808737; -.
DR   CTD; 4535; -.
DR   InParanoid; P69234; -.
DR   OMA; WSGWASN; -.
DR   Proteomes; UP000001554; Mitochondrion.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..313
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117355"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  34429 MW;  1787EA3049F0B959 CRC64;
     MILSVIHIFL YFVPVLLAVA FLTLTERKVI GYVQLRKGPN VVGPYGLLQP IADGVKLFIK
     EPIKPSSSNP SVFFFAPMLA LILALLLWMP VPLMDAFIEL NFAVLFVLAI SSLSVYSIMA
     SGWSSNSKYA LLGALRAVAQ MVSYEVSLGL IILSLICLVG GFNLAQFFSA QEEVMLMLSC
     WPLGIMWFIS TVAETNRSPF DLTEGESELV SGFNVEYSGG PFALFFLAEY ANILFMNVLS
     ALLFLAAHFS LLGVAVKVGL LAGLYLWFRA SYPRFRYDQL MHLAWKSFLP LSLGLLMLNF
     SLPLTFSGIG GGL