ID   NU1M_BRALA              Reviewed;         313 AA.
AC   P69235; O21000; O47433;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1; Synonyms=NAD1, NADH1;
OS   Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7740;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9254918; DOI=10.1093/oxfordjournals.molbev.a025821;
RA   Delarbre C., Barriel V., Tillier S., Janvier P., Gachelin G.;
RT   "The main features of the craniate mitochondrial DNA between the ND1 and
RT   the COI genes were established in the common ancestor with the lancelet.";
RL   Mol. Biol. Evol. 14:807-813(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9628930; DOI=10.1093/nar/26.13.3279;
RA   Spruyt N., Delarbre C., Gachelin G., Laudet V.;
RT   "Complete sequence of the amphioxus (Branchiostoma lanceolatum)
RT   mitochondrial genome: relations to vertebrates.";
RL   Nucleic Acids Res. 26:3279-3285(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; Y09524; CAA70708.1; -; Genomic_DNA.
DR   EMBL; Y16474; CAA76247.1; -; Genomic_DNA.
DR   PIR; B71390; B71390.
DR   RefSeq; NP_007537.1; NC_001912.1.
DR   AlphaFoldDB; P69235; -.
DR   SMR; P69235; -.
DR   GeneID; 808212; -.
DR   CTD; 4535; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..313
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117356"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        111
FT                   /note="S -> P (in Ref. 1; CAA70708)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        274
FT                   /note="R -> S (in Ref. 1; CAA70708)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  34429 MW;  1787EA3049F0B959 CRC64;
     MILSVIHIFL YFVPVLLAVA FLTLTERKVI GYVQLRKGPN VVGPYGLLQP IADGVKLFIK
     EPIKPSSSNP SVFFFAPMLA LILALLLWMP VPLMDAFIEL NFAVLFVLAI SSLSVYSIMA
     SGWSSNSKYA LLGALRAVAQ MVSYEVSLGL IILSLICLVG GFNLAQFFSA QEEVMLMLSC
     WPLGIMWFIS TVAETNRSPF DLTEGESELV SGFNVEYSGG PFALFFLAEY ANILFMNVLS
     ALLFLAAHFS LLGVAVKVGL LAGLYLWFRA SYPRFRYDQL MHLAWKSFLP LSLGLLMLNF
     SLPLTFSGIG GGL