NU1M_CAEBR
ID NU1M_CAEBR Reviewed; 291 AA.
AC Q8HEC4; B1PE35; B1PE47; B1PE59; B1PE95; B1PED1; B1PEF5; B1PEH9; B1PEK3;
AC B1PEL5; B1PEN9; B1PER3; B1PEU9; Q8HEC6;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 3.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=nd1;
OS Caenorhabditis briggsae.
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-175 AND VAL-244.
RC STRAIN=PB800;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-39; SER-67; ILE-90;
RP ASP-101; VAL-123; ILE-175; VAL-243; ALA-244; VAL-244; MET-247 AND MET-250.
RC STRAIN=BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083,
RC ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725,
RC JU726, JU793, PB800, PB826, and VT847;
RX PubMed=18302772; DOI=10.1186/1471-2148-8-62;
RA Howe D.K., Denver D.R.;
RT "Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae
RT mitochondrial genome evolution.";
RL BMC Evol. Biol. 8:62-62(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO13509.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY171102; AAO13509.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY171101; AAO13507.1; -; Genomic_DNA.
DR EMBL; EU407781; ACB06102.1; -; Genomic_DNA.
DR EMBL; EU407782; ACB06114.1; -; Genomic_DNA.
DR EMBL; EU407783; ACB06126.1; -; Genomic_DNA.
DR EMBL; EU407784; ACB06138.1; -; Genomic_DNA.
DR EMBL; EU407785; ACB06150.1; -; Genomic_DNA.
DR EMBL; EU407786; ACB06162.1; -; Genomic_DNA.
DR EMBL; EU407787; ACB06174.1; -; Genomic_DNA.
DR EMBL; EU407788; ACB06186.1; -; Genomic_DNA.
DR EMBL; EU407789; ACB06198.1; -; Genomic_DNA.
DR EMBL; EU407790; ACB06210.1; -; Genomic_DNA.
DR EMBL; EU407791; ACB06222.1; -; Genomic_DNA.
DR EMBL; EU407792; ACB06234.1; -; Genomic_DNA.
DR EMBL; EU407793; ACB06246.1; -; Genomic_DNA.
DR EMBL; EU407794; ACB06258.1; -; Genomic_DNA.
DR EMBL; EU407795; ACB06270.1; -; Genomic_DNA.
DR EMBL; EU407796; ACB06282.1; -; Genomic_DNA.
DR EMBL; EU407797; ACB06294.1; -; Genomic_DNA.
DR EMBL; EU407798; ACB06306.1; -; Genomic_DNA.
DR EMBL; EU407799; ACB06318.1; -; Genomic_DNA.
DR EMBL; EU407800; ACB06330.1; -; Genomic_DNA.
DR EMBL; EU407801; ACB06342.1; -; Genomic_DNA.
DR EMBL; EU407802; ACB06354.1; -; Genomic_DNA.
DR EMBL; EU407803; ACB06366.1; -; Genomic_DNA.
DR EMBL; AC186293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; YP_001504337.1; NC_009885.1.
DR AlphaFoldDB; Q8HEC4; -.
DR SMR; Q8HEC4; -.
DR GeneID; 5666627; -.
DR KEGG; cbr:ND1; -.
DR CTD; 4535; -.
DR InParanoid; Q8HEC4; -.
DR Proteomes; UP000008549; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..291
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117360"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 39
FT /note="P -> S (in strain: VT847)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 67
FT /note="N -> S (in strain: VT847)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 90
FT /note="T -> I (in strain: JU403, JU439, JU516 and JU793)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 101
FT /note="E -> D (in strain: ED3036)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 123
FT /note="I -> V (in strain: BW287)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 175
FT /note="V -> I (in strain: BW287, ED3033, ED3034, ED3035,
FT ED3037, ED3092, ED3101, EG4181, EG4207A, HK104, HK105,
FT JU403, JU439, JU516, JU725, JU793, PB800, PB826 and VT847)"
FT /evidence="ECO:0000269|PubMed:12644560,
FT ECO:0000269|PubMed:18302772"
FT VARIANT 243
FT /note="A -> V (in strain: ED3033, ED3034, ED3035 and
FT ED3037)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 244
FT /note="S -> A (in strain: BW287, ED3033, ED3034, ED3035,
FT ED3037, ED3092, ED3101, HK104, HK105, JU403, JU439, JU516,
FT JU793, PB826 and VT847)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 244
FT /note="S -> V (in strain: EG4181, EG4207A and PB800)"
FT /evidence="ECO:0000269|PubMed:12644560,
FT ECO:0000269|PubMed:18302772"
FT VARIANT 247
FT /note="I -> M (in strain: ED3092 and ED3101)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT VARIANT 250
FT /note="I -> M (in strain: JU793)"
FT /evidence="ECO:0000269|PubMed:18302772"
FT CONFLICT 166
FT /note="C -> Y (in Ref. 2; ACB06102/ACB06114/ACB06126/
FT ACB06138/ACB06150/ACB06162/ACB06174/ACB06186/ACB06198/
FT ACB06210/ACB06222/ACB06234/ACB06246/ACB06258/ACB06270/
FT ACB06282/ACB06294/ACB06306/ACB06318/ACB06330/ACB06366/
FT ACB06342/ACB06354)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 33377 MW; 993B7B6880348EA8 CRC64;
MILVLIMVIL MMIFIVQSIA FITLYERHLL GSSQNRLGPT KVTFMGLAQA LLDGVKLLKK
EQMTPLNSSE VSFLLVPGIS FIVMYLEWFT LPYFFDFISF EYSVLFFLCL IGFSVYTTLV
SGIVSKSKYG MIGAIRASSQ SISYEIAFSL YVLCIIIHNN VFNFMCKFNL SLLIVYIPFL
IMIIAELNRA PFDFSEGESE LVSGYNVEFA SVAFVLLFLS EYGSLIFFSV LSSAMFFSFS
ILASFSIFSI LIFIRSSYPR YRYDLMMSLF WFKLLPVSLI MLCFYAVVFY Y
