NU1M_CAEEL
ID NU1M_CAEEL Reviewed; 291 AA.
AC P24887;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 11-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03887};
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=nduo-1 {ECO:0000312|WormBase:MTCE.11};
GN Synonyms=nd1 {ECO:0000312|WormBase:MTCE.11};
GN ORFNames=MTCE.11 {ECO:0000312|WormBase:MTCE.11};
OS Caenorhabditis elegans.
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1551572; DOI=10.1093/genetics/130.3.471;
RA Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and
RT Ascaris suum.";
RL Genetics 130:471-498(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-192 AND 217-291, AND VARIANTS
RP MET-181; ASN-238 AND ILE-246.
RC STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856,
RC CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
RX PubMed=2235493; DOI=10.1093/nar/18.20.6113;
RA Okimoto R., Macfarlane J.L., Wolstenholme D.R.;
RT "Evidence for the frequent use of TTG as the translation initiation codon
RT of mitochondrial protein genes in the nematodes, Ascaris suum and
RT Caenorhabditis elegans.";
RL Nucleic Acids Res. 18:6113-6118(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:P03887}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03887};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P03887}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=X54252; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; X54252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY171133; AAO16387.1; -; Genomic_DNA.
DR EMBL; AY171134; AAO16390.1; -; Genomic_DNA.
DR EMBL; AY171135; AAO16393.1; -; Genomic_DNA.
DR EMBL; AY171136; AAO16396.1; -; Genomic_DNA.
DR EMBL; AY171137; AAO16399.1; -; Genomic_DNA.
DR EMBL; AY171138; AAO16402.1; -; Genomic_DNA.
DR EMBL; AY171139; AAO16405.1; -; Genomic_DNA.
DR EMBL; AY171140; AAO16408.1; -; Genomic_DNA.
DR EMBL; AY171141; AAO16411.1; -; Genomic_DNA.
DR EMBL; AY171142; AAO16414.1; -; Genomic_DNA.
DR EMBL; AY171143; AAO16417.1; -; Genomic_DNA.
DR EMBL; AY171144; AAO16420.1; -; Genomic_DNA.
DR EMBL; AY171145; AAO16423.1; -; Genomic_DNA.
DR EMBL; AY171146; AAO16426.1; -; Genomic_DNA.
DR EMBL; AY171147; AAO16429.1; -; Genomic_DNA.
DR EMBL; AY171148; AAO16310.1; -; Genomic_DNA.
DR EMBL; AY171149; AAO16312.1; -; Genomic_DNA.
DR EMBL; AY171150; AAO16314.1; -; Genomic_DNA.
DR EMBL; AY171151; AAO16316.1; -; Genomic_DNA.
DR EMBL; AY171152; AAO16318.1; -; Genomic_DNA.
DR EMBL; AY171153; AAO16320.1; -; Genomic_DNA.
DR EMBL; AY171154; AAO16322.1; -; Genomic_DNA.
DR EMBL; AY171155; AAO16324.1; -; Genomic_DNA.
DR EMBL; AY171156; AAO16326.1; -; Genomic_DNA.
DR EMBL; AY171157; AAO16328.1; -; Genomic_DNA.
DR EMBL; AY171158; AAO16330.1; -; Genomic_DNA.
DR EMBL; AY171159; AAO16332.1; -; Genomic_DNA.
DR EMBL; AY171160; AAO16334.1; -; Genomic_DNA.
DR EMBL; AY171161; AAO16336.1; -; Genomic_DNA.
DR EMBL; AY171162; AAO16338.1; -; Genomic_DNA.
DR PIR; S26028; S26028.
DR AlphaFoldDB; P24887; -.
DR SMR; P24887; -.
DR STRING; 6239.MTCE.11; -.
DR EPD; P24887; -.
DR PaxDb; P24887; -.
DR WormBase; MTCE.11; CE34065; WBGene00010959; nduo-1.
DR eggNOG; KOG4770; Eukaryota.
DR HOGENOM; CLU_015134_0_1_1; -.
DR InParanoid; P24887; -.
DR PhylomeDB; P24887; -.
DR PRO; PR:P24887; -.
DR Proteomes; UP000001940; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..291
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117361"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 181
FT /note="I -> M (in strain: CB4853 and CB4858)"
FT /evidence="ECO:0000269|PubMed:12644560"
FT VARIANT 238
FT /note="K -> N (in strain: Bristol N2, CB4855, CB4857,
FT CB4858 and KR314)"
FT /evidence="ECO:0000269|PubMed:12644560"
FT VARIANT 246
FT /note="S -> I (in strain: CB4854)"
FT /evidence="ECO:0000269|PubMed:12644560"
SQ SEQUENCE 291 AA; 33667 MW; D8E73DC8BA4A628D CRC64;
MILVLLMVIL MMIFIVQSIA FITLYERHLL GSSQNRLGPT KVTFMGLAQA LLDGVKLLKK
EQMTPLNSSE VSFLLVPGIS FVVMYLEWFT LPYFFDFISF EYSVLFFLCL IGFSVYTTLI
SGIVSKSKYG MIGAIRASSQ SISYEIAFSL YVLCIIIHNN VFNFVSKFNL SLLIIYIPFL
IMVIAELNRA PFDFSEGERE LVRGFNVEFA RVAFVLLFLS EYGSLIFFSV LSSAMFFKFS
IFMAFSIFSL LIFIRSSYPR YRYDLMMSLF WFKLLPISLI MLCFYAVIFY Y