ID   NU1M_CANAL              Reviewed;         317 AA.
AC   Q9B8D6;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=NAD1; OrderedLocusNames=CM_00060W {ECO:0000312|CGD:CAL0000201667};
GN   ORFNames=CaalfMp03;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=11208783; DOI=10.1128/jb.183.3.865-872.2001;
RA   Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T.,
RA   Kohn L.M.;
RT   "Infrequent genetic exchange and recombination in the mitochondrial genome
RT   of Candida albicans.";
RL   J. Bacteriol. 183:865-872(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; AF285261; AAG59589.2; -; Genomic_DNA.
DR   RefSeq; NP_075032.2; NC_002653.1.
DR   AlphaFoldDB; Q9B8D6; -.
DR   SMR; Q9B8D6; -.
DR   STRING; 237561.Q9B8D6; -.
DR   GeneID; 802557; -.
DR   KEGG; cal:CaalfMp03; -.
DR   CGD; CAL0000201667; NAD1.
DR   VEuPathDB; FungiDB:CM_00060W; -.
DR   InParanoid; Q9B8D6; -.
DR   Proteomes; UP000000559; Mitochondrion.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:CGD.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:CGD.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:CGD.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..317
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000356875"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  34779 MW;  8E1CE069C563E6D3 CRC64;
     MQYIELLIMF LSVLLAVAFL TVAERKTLGY MQRRVGPNAV GYYGILMAIA DAAKLLLKEI
     VVPTHADKLI LFVSPMISLI SALLCWSVIP FAPGVTIYDS NYGFILTLAI SSVGVFGTLL
     AGWSANSKYS LLGSIRSTAQ LISYELVLTT IILLCILIGG TMNVSKYIEI QQAIWYGIPL
     LPLAIIFFIG CVAECARPPF DNVEAESELV SGHMTEYSSS IFVLFFLSEY ASILFLSTLT
     AILFMGGGTG IILGLKANLF AFTYIWVRAT LPRVRYDKLI NLCWMIFLPI LFGSAIAVPA
     YLYALDAIII LYRPGGL