ID   NU1M_CHLRE              Reviewed;         292 AA.
AC   P11658;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1; Synonyms=NAD1;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cw15;
RX   PubMed=2463163; DOI=10.1002/j.1460-2075.1988.tb03226.x;
RA   Boer P.H., Gray M.W.;
RT   "Genes encoding a subunit of respiratory NADH dehydrogenase (ND1) and a
RT   reverse transcriptase-like protein (RTL) are linked to ribosomal RNA gene
RT   pieces in Chlamydomonas reinhardtii mitochondrial DNA.";
RL   EMBO J. 7:3501-3508(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cw15;
RA   Gray M.W.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; X54860; CAA38645.1; -; Genomic_DNA.
DR   EMBL; U03843; AAB93446.1; -; Genomic_DNA.
DR   PIR; S01650; S01650.
DR   RefSeq; NP_042570.1; NC_001638.1.
DR   AlphaFoldDB; P11658; -.
DR   SMR; P11658; -.
DR   STRING; 3055.AAB93446; -.
DR   TCDB; 3.D.1.6.4; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR   GeneID; 801499; -.
DR   KEGG; cre:ChrepMp07; -.
DR   eggNOG; KOG4770; Eukaryota.
DR   HOGENOM; CLU_015134_0_1_1; -.
DR   OrthoDB; 1214989at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..292
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117367"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   292 AA;  31590 MW;  15D58DE29E9179AD CRC64;
     MIVASILILI VPVLLSVAMF TLAERTVMAS MQRRFGPQVS GISGLLQPFW DGLKLGVKEP
     VLPDSSSAGA FAASPMISFV LSQVAWVGIC ISDASFQGLV IMAISSLAVY GVMLAGWASN
     SKYAFLGCLR SVALMVSYEL SLGAALLSIG LFVTDGTGMK CLNFAEMPTT PQYAMLPLCL
     IFLVCILAET KRDPFDLPEA ELVAGYNVEY SSLGFALFFI AEYANMAVMS AIASIYFLGG
     FSALKITALF FAFVWTRGTL PRYRYDQFMR LGWKAFLPLT LAFFALHASV AI