NU1M_CITLA
ID NU1M_CITLA Reviewed; 316 AA.
AC P08834;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 07-OCT-2020, entry version 92.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ND1; Synonyms=NAD1;
OS Citrullus lanatus (Watermelon) (Citrullus vulgaris).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus.
OX NCBI_TaxID=3654;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3447741; DOI=10.1007/bf00418532;
RA Stern D.B., Bang A.G., Thompson W.F.;
RT "The watermelon mitochondrial URF-1 gene: evidence for a complex
RT structure.";
RL Curr. Genet. 10:857-869(1986).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=3, 13, 30, 198, 252, 262, 308;
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; X04130; CAA27743.1; ALT_SEQ; Genomic_DNA.
DR PIR; S57850; S57850.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; RNA editing; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..316
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117370"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 316 AA; 35848 MW; 0B5ED833C626E044 CRC64;
MSWPILTSFM RSWTTKPPPQ IKMSPMRLSW QEPFFDCDFF CGFGQVIEAK ERCFPSVKSR
YRPPHAPPVR LPRNRKGRTG ARASWVGVKS RKRGGGLLGT FTPLYSKYAF LGALRSAAQM
VPYEVSIGLI LIVRLICVGP RNSSEIVMAQ KQIWSGIPLF PVLVMFFISR LAETNRAPFD
LPEAEAESVA GYNVEYAWDA ILNSPLLAEA NVPGXPGTHS DNKITLFILI GVDACRGREL
FILHSKLMNV GWKVFLPLSL AWVVAVSFLQ ILLLFIKAHP NLRRDYALAL SYHLYNWGSS
FIDGFFFWKR EKKNFL
