ID   NU1M_COTJA              Reviewed;         324 AA.
AC   P24968; Q8SEX3;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=11736810; DOI=10.1046/j.1365-2052.2001.00795.x;
RA   Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.;
RT   "Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial
RT   genome and its genetic relationship with related species.";
RL   Anim. Genet. 32:380-385(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 253-324.
RC   TISSUE=Liver;
RX   PubMed=1706782; DOI=10.1007/bf02515387;
RA   Desjardins P., Morais R.;
RT   "Nucleotide sequence and evolution of coding and noncoding regions of a
RT   quail mitochondrial genome.";
RL   J. Mol. Evol. 32:153-161(1991).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; AP003195; BAB62915.1; -; Genomic_DNA.
DR   EMBL; X57246; CAA40522.1; -; Genomic_DNA.
DR   PIR; S25422; S25422.
DR   RefSeq; NP_572014.1; NC_003408.1.
DR   AlphaFoldDB; P24968; -.
DR   SMR; P24968; -.
DR   Ensembl; ENSCJPT00005000007; ENSCJPP00005000002; ENSCJPG00005000007.
DR   GeneID; 804668; -.
DR   KEGG; cjo:804668; -.
DR   CTD; 4535; -.
DR   GeneTree; ENSGT00390000006621; -.
DR   OrthoDB; 1214989at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..324
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117373"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  36157 MW;  25C98AD973E3D5A8 CRC64;
     MTLSTLTSLM IMTLSYMIPI LIAVAFLTLV ERKILSYMQA RKGPNIVGPF GLLQPIADGV
     KLFIKEPIRP STSSPFLFIL TPILALLLAL TIWTPLPLPF PMTDLNLGLL FLLAMSSLTV
     YSLLWSGWAS NSKYALIGAL RAVAQTISYE VTLAIILLST IMLSGNYTLS TLSITQEPMY
     LIFSSWPLTM MWYISTLAET NRAPFDLTEG ESELVSGFNV EYAAGPFALF FLAEYANIML
     MNTLTITLFL NPSFLSPPSE LFSITLATKV LLLSSSFLWI RASYPRFRYD QLMHLLWKNF
     LPLTLAMCLW HTSMPISYAG LPPA