NU1M_DANRE
ID NU1M_DANRE Reviewed; 324 AA.
AC Q9MIZ0;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03886};
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=mt-nd1; Synonyms=mtnd1, nd1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX PubMed=11691861; DOI=10.1101/gr.156801;
RA Broughton R.E., Milam J.E., Roe B.A.;
RT "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome
RT and evolutionary patterns in vertebrate mitochondrial DNA.";
RL Genome Res. 11:1958-1967(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03886}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03886};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03887}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC024175; AAF74297.1; -; Genomic_DNA.
DR RefSeq; NP_059331.1; NC_002333.2.
DR AlphaFoldDB; Q9MIZ0; -.
DR SMR; Q9MIZ0; -.
DR STRING; 7955.ENSDARP00000087869; -.
DR PaxDb; Q9MIZ0; -.
DR Ensembl; ENSDART00000093596; ENSDARP00000087869; ENSDARG00000063895.
DR GeneID; 140531; -.
DR KEGG; dre:140531; -.
DR CTD; 4535; -.
DR ZFIN; ZDB-GENE-011205-7; mt-nd1.
DR eggNOG; KOG4770; Eukaryota.
DR GeneTree; ENSGT00390000006621; -.
DR HOGENOM; CLU_015134_0_1_1; -.
DR InParanoid; Q9MIZ0; -.
DR OMA; WSGWASN; -.
DR OrthoDB; 1214989at2759; -.
DR PhylomeDB; Q9MIZ0; -.
DR TreeFam; TF352957; -.
DR Reactome; R-DRE-611105; Respiratory electron transport.
DR Reactome; R-DRE-6799198; Complex I biogenesis.
DR PRO; PR:Q9MIZ0; -.
DR Proteomes; UP000000437; Mitochondrion MT.
DR Proteomes; UP000814640; Mitochondrion.
DR Bgee; ENSDARG00000063895; Expressed in brain and 21 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..324
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117357"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 324 AA; 35738 MW; FF5DADD76649B73D CRC64;
MLDILTSHLI NPLAYAVPVL IAVAFLTLVE RKVLGYMQLR KGPNVMGPRG LLQSVADGVK
LFIKEPIRPS MASPILFLTA PVLALILAMM LWAPMPMPYP VLDLNLGILF IMAISSLAVY
SILGSGWASN SKYALIGALR AVAQTISYEV SLGLILLSAV IFSGGYTLQT FNTTQEDTWL
LLPLWPLAIM WFISTLAETN RAPFDLTEGE SELVSGFNVE YAAGPFALFF LAEYSNILLM
NTHSTVLFLG ASFTPDAPEL MTISIATKTA MLSILFLWMR ASYPRFRYDQ LMHLIWKNFL
PITLVLVLWH IALPIALAGL PPQT