NU1M_DICDI
ID NU1M_DICDI Reviewed; 317 AA.
AC Q37313;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=nad1; ORFNames=DDB_G0294018;
OS Dictyostelium discoideum (Slime mold).
OG Mitochondrion.
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=7736610; DOI=10.1007/bf00326157;
RA Angata K., Kuroe K., Yanagisawa K., Tanaka Y.;
RT "Codon usage, genetic code and phylogeny of Dictyostelium discoideum
RT mitochondrial DNA as deduced from a 7.3-kb region.";
RL Curr. Genet. 27:249-256(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=10821186; DOI=10.1007/pl00008685;
RA Ogawa S., Yoshino R., Angata K., Iwamoto M., Pi M., Kuroe K., Matsuo K.,
RA Morio T., Urushihara H., Yanagisawa K., Tanaka Y.;
RT "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene
RT content and genome organization.";
RL Mol. Gen. Genet. 263:514-519(2000).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; D16466; BAA03935.1; -; Genomic_DNA.
DR EMBL; AB000109; BAA78063.1; -; Genomic_DNA.
DR PIR; S68157; S68157.
DR RefSeq; NP_050081.1; NC_000895.1.
DR AlphaFoldDB; Q37313; -.
DR SMR; Q37313; -.
DR GeneID; 2193907; -.
DR KEGG; ddi:DidioMp14; -.
DR dictyBase; DDB_G0294018; nad1.
DR InParanoid; Q37313; -.
DR OMA; WSGWASN; -.
DR PhylomeDB; Q37313; -.
DR PRO; PR:Q37313; -.
DR Proteomes; UP000002195; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..317
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117381"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 317 AA; 34545 MW; A0DE4CA975A44E14 CRC64;
MENMLYIIIE GGLKSLIVII GLLIGVAFAT LLERKVMAAM QKRRGPNVVG FVGLLQPLAD
GLKLVLKETI IPIVADKLIY AIAPILTFTI SIVLWSVIAV GVQSVFASIN SGVIFILAIS
SIGVYGIILA GWASNSKYAF LGGLRSAAQM VSYEVALGLI ILSIITYAGT VNLQEIMENQ
EKVWFIIPLL PGFLLAFISA LTETNRPPFD LPEAEAELVS GYNVEYSSTG FALFFLGEYA
NIILMSVLLS VFFLGGIVSN KILGAMKGVG MLCSFIWVRA TLPRYRYDQL MYLGWKSLLP
FALLIYIGVI SMVLIIK
