NU1M_DROPE
ID NU1M_DROPE Reviewed; 315 AA.
AC P84294; A8W3Q1; C9QNT7; P51933; P51935; P51936; Q34339; Q34366; Q34370;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=mt:ND1; Synonyms=ND1;
OS Drosophila persimilis (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-155 AND 305-315.
RX PubMed=7528808; DOI=10.1007/bf00173417;
RA Barrio E., Latorre A., Moya A.;
RT "Phylogeny of the Drosophila obscura species group deduced from
RT mitochondrial DNA sequences.";
RL J. Mol. Evol. 39:478-488(1994).
RN [3]
RP IDENTIFICATION.
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=19533212; DOI=10.1007/s00239-009-9255-0;
RA Montooth K.L., Abt D.N., Hofmann J.W., Rand D.M.;
RT "Comparative genomics of Drosophila mtDNA: Novel features of conservation
RT and change across functional domains and lineages.";
RL J. Mol. Evol. 69:94-114(2009).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA76661.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; EU189432; ABW37424.1; -; Genomic_DNA.
DR EMBL; U07327; AAA76660.1; -; Genomic_DNA.
DR EMBL; U07328; AAA76661.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006337; DAA06220.1; -; Genomic_DNA.
DR AlphaFoldDB; P84294; -.
DR SMR; P84294; -.
DR FlyBase; FBgn0012643; Dper\mt:ND1.
DR Proteomes; UP000008744; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..315
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117396"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 315 AA; 36399 MW; EE757D383222231D CRC64;
MFYMEFILSL IGSLLLIICV LVSVAFLTLL ERKVLGYIQI RKGPNKVGLM GIPQPFCDAI
KLFTKEQTYP LLSNYLSYYI SPIFSLFLSL FVWMCMPFFV KLYSFNLGGL FFLCCTSLGV
YTVMIAGWSS NSNYALLGGL RAVAQTISYE VSLALILLSF VFLIGSYNMM YFFYYQIYIW
FLIILFPMAL VWLTISLAET NRTPFDFAEG ESELVSGFNV EYSSGGFALI FMAEYASILF
MSMLFCVIFL GCDVFNLLFY VKLTFISFVF IWARGTLPRF RYDKLMYLAW KCFLSFSLNY
LLFFIGFKIL LFSFL
