ID   NU1M_DROSU              Reviewed;         312 AA.
AC   P51937; Q34380;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=mt:ND1; Synonyms=ND1;
OS   Drosophila subobscura (Fruit fly).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7241;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-152 AND 302-312.
RX   PubMed=7528808; DOI=10.1007/bf00173417;
RA   Barrio E., Latorre A., Moya A.;
RT   "Phylogeny of the Drosophila obscura species group deduced from
RT   mitochondrial DNA sequences.";
RL   J. Mol. Evol. 39:478-488(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-312.
RC   STRAIN=SSP. TUE 3;
RX   PubMed=1454843; DOI=10.1073/pnas.89.23.11528;
RA   Volz-Lingenhohl A., Solignac M., Sperlich D.;
RT   "Stable heteroplasmy for a large-scale deletion in the coding region of
RT   Drosophila subobscura mitochondrial DNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:11528-11532(1992).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; U07287; AAA76625.1; -; Genomic_DNA.
DR   EMBL; U07288; AAA76626.1; -; Genomic_DNA.
DR   EMBL; X65130; CAA46260.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51937; -.
DR   SMR; P51937; -.
DR   PRIDE; P51937; -.
DR   FlyBase; FBgn0012956; Dsub\mt:ND1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..312
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117397"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  35877 MW;  AFD1B33BC2BCDE68 CRC64;
     MEFILSLIGS LLLIICVLVS VAFLTLLERK VLGYIQIRKG PNKVGLMGIP QPFCDAIKLF
     TKEQTYPLLS NYLSYYISPI FSLFLSLFVW MCMPFFVKLY SFNLGGLFFL CCTSLGVYTV
     MVAGWSSNSN YALLGGLRAV AQTISYEVSL ALILLSFVFL IGSYNMVYFF YYQIYVWFLI
     ILFPMALVWL TISLAETNRT PFDFAEGESE LVSGFNVEYS SGGFALIFMA EYASILFMSM
     LFCVIFLGCD VFNLLFYVKL TFISFIFIWA RGTLPRFRYD KLMYLAWKCF LSFSLNYLLF
     FIGFKILLFS LL