ID   NU1M_DROYA              Reviewed;         324 AA.
AC   P07710;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=mt:ND1; Synonyms=ND1;
OS   Drosophila yakuba (Fruit fly).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6328435; DOI=10.1093/nar/12.9.3747;
RA   Clary D.O., Wahleithner J.A., Wolstenholme D.R.;
RT   "Sequence and arrangement of the genes for cytochrome b, URF1, URF4L, URF4,
RT   URF5, URF6 and five tRNAs in Drosophila mitochondrial DNA.";
RL   Nucleic Acids Res. 12:3747-3762(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2317.6 Ivory Coast;
RX   PubMed=3001325; DOI=10.1007/bf02099755;
RA   Clary D.O., Wolstenholme D.R.;
RT   "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence,
RT   gene organization, and genetic code.";
RL   J. Mol. Evol. 22:252-271(1985).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; X03240; CAA26997.1; -; Genomic_DNA.
DR   PIR; D30020; D30020.
DR   RefSeq; NP_006914.1; NC_001322.1.
DR   AlphaFoldDB; P07710; -.
DR   SMR; P07710; -.
DR   GeneID; 807627; -.
DR   KEGG; dya:ND1; -.
DR   CTD; 4535; -.
DR   FlyBase; FBgn0013183; Dyak\mt:ND1.
DR   Proteomes; UP000002282; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..324
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117400"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  37529 MW;  D3F20A5968463196 CRC64;
     MEFILSLIGS LLLIICVLVS VAFLTLLERK VLGYIQIRKG PNKVGLMGIP QPFCDAIKLF
     TKEQTYPLLS NYLSYYISPI FSLFLSLFVW MCMPFFVKLY SFNLGGLFFL CCTSLGVYTV
     MVAGWSSNSN YALLGGLRAV AQTISYEVSL ALIMLSFIFL IGSYNMIYFF YYQIYMWFLI
     ILFPMSLVWL TISLAETNRT PFDFAEGESE LVSGFNVEYS SGGFALIFMA EYASILFMSM
     LFCVIFLGCD VFNLLFYVKL TFISFVFIWA RGTLPRFRYD KLMYLAWKCF LSFSLNYLLF
     FIGFKILLFS FLLWIFFSKK LMEN