NU1M_FELCA
ID NU1M_FELCA Reviewed; 318 AA.
AC P48900;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03886};
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Felis catus (Cat) (Felis silvestris catus).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000312|Proteomes:UP000011712}; TISSUE=Blood;
RX PubMed=8660972; DOI=10.1006/geno.1996.0188;
RA Lopez J.V., Cevario S., O'Brien S.J.;
RT "Complete nucleotide sequences of the domestic cat (Felis catus)
RT mitochondrial genome and a transposed mtDNA tandem repeat (Numt) in the
RT nuclear genome.";
RL Genomics 33:229-246(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-115.
RX PubMed=7932781; DOI=10.1007/bf00163806;
RA Lopez J.V., Yuhki N., Masuda R., Modi W., O'Brien S.J.;
RT "Numt, a recent transfer and tandem amplification of mitochondrial DNA to
RT the nuclear genome of the domestic cat.";
RL J. Mol. Evol. 39:174-190(1994).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03886}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03886};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03887}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; U20753; AAC48569.1; -; Genomic_DNA.
DR EMBL; S75096; AAB32045.1; -; Genomic_DNA.
DR PIR; T11402; T11402.
DR RefSeq; NP_008251.1; NC_001700.1.
DR AlphaFoldDB; P48900; -.
DR SMR; P48900; -.
DR STRING; 9685.ENSFCAP00000025722; -.
DR Ensembl; ENSFCAT00000032633; ENSFCAP00000025722; ENSFCAG00000032048.
DR GeneID; 807939; -.
DR KEGG; fca:807939; -.
DR CTD; 4535; -.
DR eggNOG; KOG4770; Eukaryota.
DR GeneTree; ENSGT00390000006621; -.
DR HOGENOM; CLU_015134_0_1_1; -.
DR InParanoid; P48900; -.
DR OMA; WSGWASN; -.
DR OrthoDB; 1214989at2759; -.
DR Proteomes; UP000011712; Mitochondrion.
DR Bgee; ENSFCAG00000032048; Expressed in prefrontal cortex and 9 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..318
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117406"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 318 AA; 35874 MW; D70995426FA765AE CRC64;
MFMINVLSLI IPILLAVAFL TLVERKVLGY MQLRKGPNVV GPYGLLQPIA DAVKLFTKEP
LRPLTSSMLM FIMAPILALT LALTMWIPLP MPYPLINMNL GVLFMLAMSS LAVYSILWSG
WASNSKYALI GALRAVAQTI SYEVTLAIIL LSVLLMNGSF TLAMLITTQE YMWLIIPAWP
LAMMWFISTL AETNRAPFDL TEGESELVSG FDVEYAAGPF ALFFLAEYAN IIMMNILTTI
LFFGAFHSPY MPELYTINFT VKTLLLTTTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
CMWHVSLPII TASIPPQT
