NU1M_HETBL
ID NU1M_HETBL Reviewed; 313 AA.
AC O47479;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ND1;
OS Heterololigo bleekeri (Spear squid) (Loligo bleekeri).
OG Mitochondrion.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Decapodiformes; Teuthida; Myopsina; Loliginidae; Heterololigo.
OX NCBI_TaxID=1423826;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Tomita K., Ueda T., Watanabe K.;
RT "Completing of squid (Loligo breekeri) mitochondrial genome sequencing.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AB009838; BAA24062.1; -; Genomic_DNA.
DR EMBL; AB029616; BAB03649.1; -; Genomic_DNA.
DR RefSeq; NP_062837.1; NC_002507.1.
DR AlphaFoldDB; O47479; -.
DR SMR; O47479; -.
DR GeneID; 809445; -.
DR CTD; 4535; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..313
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117421"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 313 AA; 34914 MW; FB3E1511F8C710CF CRC64;
MMLVELLSGV ISCVCALLAV AFFTLLERKG LGYFQLRKGP NKVGLMGLPQ PLADAVKLFT
EELVKPTLVN VFPFLVCPAM SLFLALVLWI LYNNYFVCSM GGLSMLLFLC VSSLGVYSVM
GAGWFSNSKY ALLGSVRAVA QSISYEVSMS LILMSCLLLV GSMSLSMIMK YQFFVWVAFV
NFFMMLMWFV SCVAETHRAP FDFAEGESEL VSGFNTEYGG VGFALLFMAE YGNILFMSVL
VISLFFGGVV FVGVFGMGLC VMVSFVGWLF IWVRASYPRY RYDLLMYLIW KSYLPSVLSI
LMFLVVSVYI LNG
