ID   NU1M_HYACU              Reviewed;         297 AA.
AC   Q950U8;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000250|UniProtKB:P03887};
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03887};
DE   AltName: Full=NADH dehydrogenase subunit 1 {ECO:0000250|UniProtKB:P03887};
GN   Name=nd1 {ECO:0000250|UniProtKB:P03887};
GN   Synonyms=nad1 {ECO:0000312|EMBL:AAK83418.1};
OS   Hyaloraphidium curvatum (Lower fungus).
OG   Mitochondrion {ECO:0000312|EMBL:AAK83418.1}.
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Monoblepharidomycetes; Monoblepharidales;
OC   Monoblepharidales incertae sedis; Hyaloraphidium.
OX   NCBI_TaxID=82268;
RN   [1] {ECO:0000312|EMBL:AAK83418.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAG 235-1 / CCAP 235/1;
RX   PubMed=11861890; DOI=10.1093/oxfordjournals.molbev.a004084;
RA   Forget L., Ustinova J., Wang Z., Huss V.A.R., Lang B.F.;
RT   "Hyaloraphidium curvatum: a linear mitochondrial genome, tRNA editing, and
RT   an evolutionary link to lower fungi.";
RL   Mol. Biol. Evol. 19:310-319(2002).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250|UniProtKB:P03887}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P03887}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000255}.
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DR   EMBL; AF402142; AAK83418.1; -; Genomic_DNA.
DR   RefSeq; NP_150096.1; NC_003048.1.
DR   AlphaFoldDB; Q950U8; -.
DR   SMR; Q950U8; -.
DR   GeneID; 803624; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..297
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000411057"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  33187 MW;  D57307E0F9410741 CRC64;
     MKSLIVALAI VLAVAFMTLA ERKLMGSIQR RLGPNHVGFL GLLQPFADGI KLILKETVLP
     LEANHWLFVL APFLSFYLAL LNWLVIPLAK GVVLMDMDLS ILLILAISSL GVYAIIYTGW
     SANSKYTLLG SLRSTAQMVS YEIAMSLLVL TVVYMGATLN LTELAYLNSG TVLLWSLWPM
     AMIGFVAALA ETNRAPFDLP EAESELVAGF MTEHSAISFT FLFLGEYANI ITISTVLNLM
     FLGFYNPLVI YLFIWIRATL PRLRFDQLLR LGWQYLLPFL IGFLMIQPST LFVLDLF