ID   NU1M_LATCH              Reviewed;         323 AA.
AC   O03847;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Latimeria chalumnae (Coelacanth).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9215903; DOI=10.1093/genetics/146.3.995;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; U82228; AAC60318.1; -; Genomic_DNA.
DR   PIR; A58892; A58892.
DR   RefSeq; NP_008329.1; NC_001804.1.
DR   AlphaFoldDB; O03847; -.
DR   SMR; O03847; -.
DR   STRING; 7897.ENSLACP00000021805; -.
DR   Ensembl; ENSLACT00000024845; ENSLACP00000021805; ENSLACG00000022061.
DR   GeneID; 808083; -.
DR   KEGG; lcm:808083; -.
DR   CTD; 4535; -.
DR   eggNOG; KOG4770; Eukaryota.
DR   GeneTree; ENSGT00390000006621; -.
DR   HOGENOM; CLU_015134_0_1_1; -.
DR   InParanoid; O03847; -.
DR   OMA; WSGWASN; -.
DR   OrthoDB; 1214989at2759; -.
DR   TreeFam; TF352957; -.
DR   Proteomes; UP000008672; Mitochondrion.
DR   Bgee; ENSLACG00000022061; Expressed in pelvic fin and 6 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..323
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117417"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   323 AA;  35729 MW;  A2A6440F7689299B CRC64;
     MTKIITHLLN PLAVIIPILL AVAFLTLIER KVLGYMQLRK GPNIVGPYGL LQPLADGLKL
     FIKEPVRPST SSPLLFITTP MLALTMALTL WLPLPLPHPM TNLNLGMLFI LAISSLTVYS
     ILGSGWASNL KYALIGALRA VAQTISYEVS LGLILLAMII FAGGFTLTTF NTSQETIWLL
     TPGWPLAAMW YISTLAETNR APFDLTEGES ELVSGFNVEY AGGPFALFFL AEYANILLMN
     TLSTILFMGA MHNPITPELT SINLMIKASA LSMLFLWVRA SYPRFRYDQL MHLVWKNFLP
     ITLAMILWHT SLPIFTGSLP PQT