ID   NU1M_LEMCA              Reviewed;         318 AA.
AC   O78696; Q8LX32;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03886};
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Lemur catta (Ring-tailed lemur).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Lemur.
OX   NCBI_TaxID=9447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=9732458; DOI=10.1007/pl00006389;
RA   Cao Y., Janke A., Waddell P.J., Westerman M., Takenaka O., Murata S.,
RA   Okada N., Paeaebo S., Hasegawa M.;
RT   "Conflict among individual mitochondrial proteins in resolving the
RT   phylogeny of eutherian orders.";
RL   J. Mol. Evol. 47:307-322(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12034869; DOI=10.1073/pnas.102164299;
RA   Arnason U., Adegoke J.A., Bodin K., Born E.W., Esa Y.B., Gullberg A.,
RA   Nilsson M., Short R.V., Xu X., Janke A.;
RT   "Mammalian mitogenomic relationships and the root of the eutherian tree.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:8151-8156(2002).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03886}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03886};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03887}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; AB011213; BAA32105.1; -; Genomic_DNA.
DR   EMBL; AJ421451; CAD13421.1; -; Genomic_DNA.
DR   RefSeq; NP_659288.1; NC_004025.1.
DR   AlphaFoldDB; O78696; -.
DR   SMR; O78696; -.
DR   GeneID; 804963; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..318
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117419"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        85
FT                   /note="T -> M (in Ref. 1; BAA32105)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        144
FT                   /note="F -> V (in Ref. 1; BAA32105)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   318 AA;  35797 MW;  3E4DD537F4F8E33A CRC64;
     MFMINLFLLI IPILLAMAFL TLAERKILGY MQLRKGPNVV GPHGMIQPFA DAMKLFIKEP
     LRPLTSSSSL YTIAPTLALT IALVTWIPLP LPYPLINMNM GLLFILATSS LAVYSILWSG
     WASNSKYALI GALRAVAQTI SYEFTLAIIL LSLLLMNGSF TLSTLITTQE YLWLIIPSWP
     LAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF ALFFMAEYTN IIMMNALTTT
     LFLGALYNLH MPETYTTSFA IKTLLLTILF LWVRASYPRF RYDQLMHLLW KNFLPLTLAL
     CMWYVSLPVL ASCIPPQA