ID   NU1M_LYCSM              Reviewed;         321 AA.
AC   O79546;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Lycodon semicarinatus (Ryukyu odd-tooth snake) (Eumesodon semicarinatus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Colubrinae; Lycodon.
OX   NCBI_TaxID=56549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=9725849; DOI=10.1093/genetics/150.1.313;
RA   Kumazawa Y., Ota H., Nishida M., Ozawa T.;
RT   "The complete nucleotide sequence of a snake (Dinodon semicarinatus)
RT   mitochondrial genome with two identical control regions.";
RL   Genetics 150:313-329(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; AB008539; BAA33022.1; -; Genomic_DNA.
DR   PIR; T11088; T11088.
DR   RefSeq; NP_008419.1; NC_001945.1.
DR   AlphaFoldDB; O79546; -.
DR   SMR; O79546; -.
DR   GeneID; 808264; -.
DR   CTD; 4535; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..321
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117384"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   321 AA;  36003 MW;  6907ECBAA0C2FD9D CRC64;
     MISMILLNIT NSLLYILSIL IAVAFLTLLE RKLLGYMQHR KGPNLVGPMG LLQPIADGLK
     LITKEATKPT MSSPILFTLS PIMALILALT SWAPMPMPTP LTNMNLGLLF IMAMSGMFTY
     AILWSGWSSN SKYPLMGAMR AVAQIISYEV TLGLIIISMA ILSGGYSLML FTETQEHMWL
     LLSSWPLAMM WFTSTLAETN RSPFDLTEGE SELVSGFNVE FSAGPFALLF LAEYTNILFM
     NTLSTMMFLN PGMTNPQLFT INLMTKTMIL TTLFLWTRAS YPRFRYDQLM HLLWKQYLPL
     TLAMYLLNTS TSMALCGTPP Q