ID   NU1M_MONDO              Reviewed;         318 AA.
AC   O78703;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Monodelphis domestica (Gray short-tailed opossum).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Muscle;
RX   PubMed=9732458; DOI=10.1007/pl00006389;
RA   Cao Y., Janke A., Waddell P.J., Westerman M., Takenaka O., Murata S.,
RA   Okada N., Paeaebo S., Hasegawa M.;
RT   "Conflict among individual mitochondrial proteins in resolving the
RT   phylogeny of eutherian orders.";
RL   J. Mol. Evol. 47:307-322(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; AB011220; BAA32112.1; -; Genomic_DNA.
DR   RefSeq; YP_087179.1; NC_006299.1.
DR   AlphaFoldDB; O78703; -.
DR   SMR; O78703; -.
DR   STRING; 13616.ENSMODP00000026931; -.
DR   Ensembl; ENSMODT00000027417; ENSMODP00000026931; ENSMODG00000021562.
DR   GeneID; 3074661; -.
DR   KEGG; mdo:3074661; -.
DR   CTD; 4535; -.
DR   eggNOG; KOG4770; Eukaryota.
DR   GeneTree; ENSGT00390000006621; -.
DR   HOGENOM; CLU_015134_0_1_1; -.
DR   InParanoid; O78703; -.
DR   OMA; WSGWASN; -.
DR   OrthoDB; 1214989at2759; -.
DR   TreeFam; TF352957; -.
DR   Proteomes; UP000002280; Mitochondrion.
DR   Bgee; ENSMODG00000021562; Expressed in skeletal muscle tissue and 19 other tissues.
DR   ExpressionAtlas; O78703; baseline.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..318
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117430"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  35796 MW;  2DD4A4A75B073331 CRC64;
     MFLINLLIYI IPILLAVAFL TLIERKVLGY MQLRKGPNVI GPYGILQPFA DAVKLFTKEP
     LRPLTSSISM FIIAPILALT LALTIWTPLP MPHTLIDLNL GLLFILSLSG LSVYSILWSG
     WASNSKYALI GALRAVAQTI SYEVTLAIIL LSIMLINGSF TLKNLMITQE NMWLIMTAWP
     LTMMWYISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF AMFFLAEYAN IMAMNAMTTI
     LFLGPPLNHN HTYTCTISFM FKTMLLTSAF LWVRASYPRF RYDQLMYLLW KSFLPITLAL
     CLMFISIPIA LSSIPPQM