ID   NU1M_MYTED              Reviewed;         305 AA.
AC   Q00860; Q68SR5;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1;
OS   Mytilus edulis (Blue mussel).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC   Mytilus.
OX   NCBI_TaxID=6550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RX   PubMed=15014161; DOI=10.1093/molbev/msh090;
RA   Boore J.L., Medina M., Rosenberg L.A.;
RT   "Complete sequences of the highly rearranged molluscan mitochondrial
RT   genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis.";
RL   Mol. Biol. Evol. 21:1492-1503(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50 AND 134-305.
RX   PubMed=1386586; DOI=10.1093/genetics/131.2.397;
RA   Hoffmann R.J., Boore J.L., Brown W.M.;
RT   "A novel mitochondrial genome organization for the blue mussel, Mytilus
RT   edulis.";
RL   Genetics 131:397-412(1992).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; AY484747; AAT98407.1; -; Genomic_DNA.
DR   PIR; S28749; S28749.
DR   RefSeq; YP_073338.1; NC_006161.1.
DR   AlphaFoldDB; Q00860; -.
DR   SMR; Q00860; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..305
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117434"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  33764 MW;  B1674EDFB6FEA599 CRC64;
     MDWVAVIVSI IPFVGVLLAV GFYTLLERKI LAIIMIRKGP SKVSYMGILQ PFSDAGKLLC
     KEFIVPTRAN VGPFILAPAL MLAISLLGWL LYPYKSAEVF YVFGVILFMV ITSVSVYGVM
     MSGWASNSKY SLLGAVRAMA QSISYEIPMG FIFFCVVLCS GVFMFQEISV FQQSLFFFFL
     PLCVVMLVWM LCMLAETNRA PFDFVEGESE LVSGYNVEYS GGGFAVMFIA EYSSILLSSV
     MSAAMFFGGN EALVGFFMMV FAIFFVVVRA SLPRLRYDKL MNLCWTVLLC VMLTASVCVV
     VLVGV