ID   NU1M_MYXGL              Reviewed;         318 AA.
AC   O21077; O63917;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Myxine glutinosa (Atlantic hagfish).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Myxininae; Myxine.
OX   NCBI_TaxID=7769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9254918; DOI=10.1093/oxfordjournals.molbev.a025821;
RA   Delarbre C., Barriel V., Tillier S., Janvier P., Gachelin G.;
RT   "The main features of the craniate mitochondrial DNA between the ND1 and
RT   the COI genes were established in the common ancestor with the lancelet.";
RL   Mol. Biol. Evol. 14:807-813(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9541532; DOI=10.1007/pl00006317;
RA   Rasmussen A.S., Janke A., Arnason U.;
RT   "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and
RT   vertebrate phylogeny.";
RL   J. Mol. Evol. 46:382-388(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11677623; DOI=10.1007/s002390010250;
RA   Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.;
RT   "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique
RT   features of the control region.";
RL   J. Mol. Evol. 53:634-641(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; Y09527; CAA70716.1; -; Genomic_DNA.
DR   EMBL; Y15186; CAA75485.1; -; Genomic_DNA.
DR   EMBL; AJ404477; CAC20649.1; -; Genomic_DNA.
DR   PIR; T13816; T13816.
DR   RefSeq; NP_073273.1; NC_002639.1.
DR   AlphaFoldDB; O21077; -.
DR   SMR; O21077; -.
DR   GeneID; 802347; -.
DR   CTD; 4535; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..318
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117435"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        2
FT                   /note="Missing (in Ref. 2; CAA75485)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        9
FT                   /note="F -> L (in Ref. 2; CAA75485)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   318 AA;  35692 MW;  20746DD0DB1578E1 CRC64;
     MISQIISSFL TFVMILIAVA FLTLIERKVL GYMQLRKGPN IVGPFGLLQP FADGIKLFIK
     EPLQPSYASI FLFILAPALA ISLALILWIS LPLPLALSDM NLGLMFILAI SSLSVYSLLT
     SGWASNSKYA LMGALRAVAQ TISYEVTLGL MIVALTILSG GFDLKLFIDL QNKIWLLFPM
     WPIFLMWFIS TLAETNRSPF DLTEGESELV SGFNVEFSGG LFALFFLAEY ANILFMNSLT
     VVLFMGSSNL SSLYFSASMT MKTMFLIFLF LWVRASYPRF RYDQLMHLMW KNFLPITLSL
     LIFQFSMSLF FGVSPSAI