NU1M_NEUCR
ID NU1M_NEUCR Reviewed; 371 AA.
AC P08774; M1R9S5; Q5F0G6;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ndh-1; Synonyms=ND1; ORFNames=NCU16018;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3003362; DOI=10.1016/0022-2836(85)90100-7;
RA Burger G., Werner S.;
RT "The mitochondrial URF1 gene in Neurospora crassa has an intron that
RT contains a novel type of URF.";
RL J. Mol. Biol. 186:231-242(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15670715; DOI=10.1016/j.fgb.2004.11.007;
RA D'Souza A.D., Bertrand H., Maheshwari R.;
RT "Intramolecular recombination and deletions in mitochondrial DNA of
RT senescent, a nuclear-gene mutant of Neurospora crassa exhibiting 'death'
RT phenotype.";
RL Fungal Genet. Biol. 42:178-190(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RA Kennell J.C., Collins R.A., Griffiths A.J.F., Nargang F.E.;
RT "Mitochondrial genetics of Neurospora.";
RL (In) Kueck U. (eds.);
RL The Mycota II, Genetics and Biotechnology (2nd edition), pp.95-112,
RL Springer-Verlag, Berlin-Heidelberg (2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-216, AND CONFIRMATION OF SPLICE
RP SITE.
RX PubMed=1977658; DOI=10.1093/genetics/126.1.63;
RA Hawse A., Collins R.A., Nargang F.E.;
RT "Behavior of the [mi-3] mutation and conversion of polymorphic mtDNA
RT markers in heterokaryons of Neurospora crassa.";
RL Genetics 126:63-72(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AGG16007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X03280; CAA27029.1; -; Genomic_DNA.
DR EMBL; AY548155; AAT74904.1; -; Genomic_DNA.
DR EMBL; AY548157; AAT74909.1; -; Genomic_DNA.
DR EMBL; KC683708; AGG16007.1; ALT_SEQ; Genomic_DNA.
DR PIR; A23431; A23431.
DR RefSeq; YP_009126719.1; NC_026614.1.
DR AlphaFoldDB; P08774; -.
DR SMR; P08774; -.
DR STRING; 367110.P08774; -.
DR TCDB; 3.D.1.6.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR EnsemblFungi; AGG16007; AGG16007; NCU16018.
DR GeneID; 23681573; -.
DR KEGG; ncr:NCU16018; -.
DR InParanoid; P08774; -.
DR Proteomes; UP000001805; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..371
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117436"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 371 AA; 41552 MW; 70826D8C7B87236F CRC64;
MFYSLTIISI LEVLLVLVPS LLAVAYVTVA ERKTMASMQR RLGPNAVGYL GLLQAFADAL
KLLLKEYVAL TQANMTLFFL GPVITLIFSL LGYAVIPYGP SLVIQDVNLG ILYMLAVSSL
ATYGILLAGW SANSKYAFLG SLRSAAQLIS YELVLSSAIL LVIMLTGSFN LGVNTESQRA
VLFVLPLLPI FIIFFIGSIA ETNRAPFDLA EAESELVSGF MTEHAAVVFV FFFLAEYGSI
VLMCILTSIL FLGGYLFINL KDVFNILDFV YSNLFIFEIN WMVSERSYTE DFFNNYKSIL
EGWLYGWIIG LKSSIMIFIF ILGRASFPRI RYDQLMGFCW TVLLPIIFAL IILVPCILES
FYILPWNLNL F
